Structure of PDB 1y42 Chain X Binding Site BS01

Receptor Information
>1y42 Chain X (length=370) Species: 5141 (Neurospora crassa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKYTAKINEAEENWQARAEAIKKGKKQNTWDLFEERGYVKDTAGTKEHIA
ELMRTRRIGAYVGIDPTAPSLHVGHLLPLMPLFWMYLEGYKAFTLIGGST
AKIGDPTGDATMNMTKIHYQLKKLWENVDTQMRARGYEADWARKRGIVNN
NHWWNKQPMLEVLRRVGHALRIGPMLSRDTVKNKMTQGDGVSFAEFTYPI
MQGWDWFELFYQQGVQMQIGGSDQYGNIISGLEVVKAARESEPDPQERKY
VTPKTALDECVGFTVPLLTDSSGAKFGKSAGNAIWLDPYQTSVFDFYGYF
VRRSDQEVENLLKLFTFMPISEITKTMEEHIKDPSKRVAQHTLAREVVTL
VHGKQEASAAEDQHRMMYTG
Ligand information
Ligand IDTYR
InChIInChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKeyOUYCCCASQSFEME-QMMMGPOBSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(N)Cc1ccc(O)cc1
OpenEye OEToolkits 1.5.0c1cc(ccc1C[C@@H](C(=O)O)N)O
OpenEye OEToolkits 1.5.0c1cc(ccc1CC(C(=O)O)N)O
CACTVS 3.341N[CH](Cc1ccc(O)cc1)C(O)=O
CACTVS 3.341N[C@@H](Cc1ccc(O)cc1)C(O)=O
FormulaC9 H11 N O3
NameTYROSINE
ChEMBLCHEMBL925
DrugBankDB00135
ZINCZINC000000266964
PDB chain1y42 Chain X Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1y42 A tyrosyl-tRNA synthetase adapted to function in group I intron splicing by acquiring a new RNA binding surface.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		Y99 G101 D143 Y247 Q251 D254 Q273
Binding residue
(residue number reindexed from 1)		Y61 G63 D105 Y198 Q202 D205 Q224
Annotation score5
Enzymatic activity
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1y42, PDBe:1y42, PDBj:1y42
PDBsum1y42
PubMed15694342
UniProtP12063|SYYM_NEUCR Tyrosine--tRNA ligase, mitochondrial (Gene Name=cyt-18)

[Back to BioLiP]