Structure of PDB 1pae Chain X Binding Site BS01

Receptor Information
>1pae Chain X (length=148) Species: 44689 (Dictyostelium discoideum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KERTFLAVKPDGVARGLVGEIIARYEKKGFVLVGLKQLVPTKDLAESHYA
EHKERPFFGGLVSFITSGPVVAMVFEGKGVVASARLMIGVTNPLASAPGS
IRGDFGVDVGRNIICGSDSVESANREIALWFKPEELLTEVKPNPNLYE
Ligand information
Ligand IDSE
InChIInChI=1S/H2Se/h1H2
InChIKeySPVXKVOXSXTJOY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[SeH2]
CACTVS 3.341[Se]
FormulaSe
NameSELENIUM ATOM
ChEMBLCHEMBL1235891
DrugBank
ZINC
PDB chain1pae Chain X Residue 156 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1pae Selenomethionine and Selenocysteine Double Labeling Strategy for Crystallographic Phasing
Resolution2.7 Å
Binding residue
(original residue number in PDB)		U122 G123
Binding residue
(residue number reindexed from 1)		U115 G116
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.4.6: nucleoside-diphosphate kinase.
Gene Ontology
Molecular Function
GO:0004550 nucleoside diphosphate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006183 GTP biosynthetic process
GO:0006187 dGTP biosynthetic process from dGDP
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006414 translational elongation
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009117 nucleotide metabolic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0009617 response to bacterium
GO:0016310 phosphorylation
GO:0019954 asexual reproduction
GO:0030036 actin cytoskeleton organization
GO:0045920 negative regulation of exocytosis
GO:0048550 negative regulation of pinocytosis
GO:0050765 negative regulation of phagocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0030141 secretory granule
GO:0045335 phagocytic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1pae, PDBe:1pae, PDBj:1pae
PDBsum1pae
PubMed14604526
UniProtP22887|NDKC_DICDI Nucleoside diphosphate kinase, cytosolic (Gene Name=ndkC-1)

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