Structure of PDB 1mw8 Chain X Binding Site BS01

Receptor Information
>1mw8 Chain X (length=561) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGDERGALVNRM
GVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW
HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFM
DRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWE
VDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLER
EDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMR
TDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASEAREAIRPSDVNVM
AESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARG
RILRFDGWTKVMPAEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEAS
LVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE
ENFRELMNYDFTAQMENNLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD
PEEGGMRPNQM
Ligand information
Receptor-Ligand Complex Structure
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PDB1mw8 Structure of a Complex between E. coli DNA Topoisomerase I and Single-Stranded DNA.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		E115 R169 D172 R173 G176 Y177 S180 W184 R189 G190 S192 A193 G194 V196 Q197 R321 T496 R507
Binding residue
(residue number reindexed from 1)		E94 R148 D151 R152 G155 Y156 S159 W163 R168 G169 S171 A172 G173 V175 Q176 R300 T465 R476
Enzymatic activity
Catalytic site (original residue number in PDB) E9 S10 D113 E115 Y319 R321
Catalytic site (residue number reindexed from 1) E8 S9 D92 E94 Y298 R300
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:1mw8, PDBe:1mw8, PDBj:1mw8
PDBsum1mw8
PubMed14604525
UniProtP06612|TOP1_ECOLI DNA topoisomerase 1 (Gene Name=topA)

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