Structure of PDB 8s54 Chain W Binding Site BS01

Receptor Information
>8s54 Chain W (length=187) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPAALKRLAKYVIRGFYGIEHALALDILIRNSCVKEEDMLELLKFDRKQL
RSVLNNLKGDKFIKCRMRVETAADGKTTRHNYYFINYRTLVNVVKYKLDH
MRRRIETDERDSTNRASFKCPVCSSTFTDLEANQLFDPMTGTFRCTFCHT
EVEEDESAMPKKDARTLLARFNEQIEPIYALLRETED
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8s54 Chain W Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8s54 Three-step mechanism of promoter escape by RNA polymerase II
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C129 F136 C154
Binding residue
(residue number reindexed from 1)		C120 F127 C145
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0046872 metal ion binding
Biological Process
GO:0001113 transcription open complex formation at RNA polymerase II promoter
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005673 transcription factor TFIIE complex
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8s54, PDBe:8s54, PDBj:8s54
PDBsum8s54
PubMed38604172
UniProtP29083|T2EA_HUMAN General transcription factor IIE subunit 1 (Gene Name=GTF2E1)

[Back to BioLiP]