Structure of PDB 8rch Chain W Binding Site BS01

Receptor Information
>8rch Chain W (length=428) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANL
QKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVP
RPTVNGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSF
KQFALQREQELEVSMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIK
IALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDT
IAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPP
TYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTM
GVENRNPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGI
FPYVLKLLQSSARELRPLLVFIWAKILA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rch cryoEM structure of mTORC1 with the cancer-associated 1455-EWED-1458 duplication variant, overall refinement
Resolution4.0 Å
Binding residue
(original residue number in PDB)		T317 Q438 L441 S442 Y475 K478 L479
Binding residue
(residue number reindexed from 1)		T245 Q366 L369 S370 Y403 K406 L407
External links
PDB RCSB:8rch, PDBe:8rch, PDBj:8rch
PDBsum8rch
PubMed
UniProtQ8N122|RPTOR_HUMAN Regulatory-associated protein of mTOR (Gene Name=RPTOR)

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