Structure of PDB 8q5i Chain W Binding Site BS01

Receptor Information

>8q5i Chain W (length=87) Species: 5476 (Candida albicans)

MENDKGQLVELYVPRKCSATNRIIKAKDHASVQISIAKVDEDGRAIAGEN
ITYALSGYVRGRGEADDSLNRLAQQDGLLKNVWSYSR

Ligand information

>8q5i Chain A (length=1558)

uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaau
ucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauu
uauuagagaugauucauaauaacuuuucgaaucgcauggccuugugcugg
cgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauagu
ggccuaccaugguuucaacggguaacggggaauaaggguucgauuccgga
gagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgc
aaauuacccaaucccgacacggggagguagugacaauaaauaacgauaca
gguuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauug
gagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcgu
auauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuugg
cugcagccgagccuuuuuuacuuugaaaaaauuagaguguucaaagcagg
ccuuugcucgaauauauuagcauggaauaauagaauaggacguuauaucg
uaaugauuaauagggacggucggggguaucaguauucaguugucagaggu
gaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaag
gacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucaga
uaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguug
uucugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggg
gggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcacc
accaggaguggagccugcggcuuaauuugacucaacacggggaaacucac
cagguccagacacugagagcugugggugguggugcauggccguucuuagu
ugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaacc
uacuaaauagugccacuucuuagagggacuaucgauuucaagucgaugga
aguuugaggcaauaacaggucugugaugcccuuagacguucugggccgca
cgcgcgcuacacugacggagccagcgaguauaagccuuggccgagagguc
ugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauug
uugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguu
gauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauuga
auggcuuagugaggccuccggauuggcgagaagcuggucaaacuugguca
uuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcgga
aggaucau

...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<.........<<.....<..<<.....
..>>..>......>>........<<<<<..<<....>>..>>>>><...<
<<<<<...........>>>>>>.....>...<<<<..<<<.....>>>.>
>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.....
..>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>
>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>....
.....<<<....<<<<...>>>>..>>>..>....>.>.....<<<<...
<..>...>>>>......<<..<...........>..>>.........<<<
<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>
>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<<<
<<..>>>>>>>>>>...<<<<<.<<.......<<...<.......>..<<
<....>>>....>>......>>.>>..>>>.........<<<..<..>>>
>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<..
....>>>......>.>>>>>>..>>.......<<....>>...>>>>...
>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<....
.>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..
<<..>>.>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<
<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..
<<.<<<<<<..<<<.<<<<.<......<<........>>..........<
<<<<.<....<<<........>>>...<<.<<<..<<.<<<<<<....<<
<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<
..<<<<..<<<<.>>>>..>>>>.>>....<<<<<<.....>>>>>>...
....>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>..
>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>
.>>>....>>.......>>>>>>>...........<<<<<<.........
.>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>
......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<
<<<<<<.<<<..<<<<..<...<<<.>>>...>..>>>>..>>>.>>>>>
>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>
>.......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8q5i Structural characterization of cephaeline binding to the eukaryotic ribosome using Cryo-Electron Microscopy
• Resolution: 2.45 Å
• Binding residue (original residue number in PDB): Y58 R62
• Binding residue (residue number reindexed from 1): Y58 R62

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006364 rRNA processing
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8q5i, PDBe:8q5i, PDBj:8q5i
• PDBsum: 8q5i
• UniProt: Q9P844|RS21_CANAX Small ribosomal subunit protein eS21 (Gene Name=RPS21)