Structure of PDB 8ovj Chain W Binding Site BS01

Receptor Information
>8ovj Chain W (length=118) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KCGSRRKARRAHFQAPSHVRRVLMSAPLSKELRAKYNVRAMPVRKDDEVI
VKRGTFKGREGKVTACYRLKWVILIDKVNREKANGSTVAVGIHPSNVEIT
KLKLTHHRKSILERKDRS
Ligand information
>8ovj Chain 1 (length=1611) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacucag
cggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaaga
gggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggc
acgugugguuggugcaggaguggcgaaauucaagcgaaaagcaaacccgu
ugcugaauacaacccuucaugugaguauugagccaaagaagguguuagcc
cauugagccauaaaccugagcgccucaugaacaagcgaguagcacuguuu
gggaaugcagugucaaguggcagguauuugucugccaaaguuaaauacag
aguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagc
acuuuggaaagagagugaaauagaaccugaagucgugacaaagacaaugg
aaguaccuccauuucaacggccagaaccagcccuacugcauuauccuguc
ggggaucaaaauccggcgggcaacgaagugcaagaaugggucuuggugaa
augagcggaguauuugugcugcgcacggcggccgcacgcacugguuucuu
cuccgugaugcuccauguuggcgauggaaauggggugcccccacccgucu
ugaaacacggaccaaggagucaaacagacgcgcaagggaggagauaugcc
aguacuucucucguacugaaagggagaugcaaaaugcaucuguggugugc
acacgucaaauccguuugauuugcccaacaccgaccggcccuccgugggu
ugcguuggagugugccuguuuggacccgaaagguggugaacuaugccuga
acaaggugaagcccggggaaacccagguggaggccuguagcgaugcugac
gugcaaaucgcucguaugauuuggguaucggagcgaaagacucaucgaac
caccuaguagcugguucacaucgaaguuucccucaggauagcuggugcua
guagaaguauugugcgguaaagcaaaugauuagaggcgaccuauucucaa
acuuuaaaugugcaaacaaaccggccuuagccaacugcaaggccggaaag
aaaagaauuagaggcaccaagugggccuucuucgguaagcggagcaggcg
augcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcuca
uucucgauacgugaaaaggguugguggauccaccggccccgaaaauggau
gacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcgg
aaacaaaggagaaaguguagcccuuccgauguagauguggccuggagguu
aggacgaagcuuauggcgugagccuaagauggaccggccucuagugcaga
ucuugguuggcguagcaaagaucuaacggagauauacucaacaugcaacg
uuggauacuggagcggggaaggauuucgugccaacggcacucguacacga
guuguucggaaacugagcacaacguuauaucguuuuguuaggaaagugaa
ggaacugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaa
uugcauguggg
.......................<<<<<......<......>.......>
>>>.>.........<<....>>..<<<<<<......<<.....>>....>
>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>
>..<<<<...<<<<<<<<.<<<<<......<<<......<<<<.......
>>>>.....<<........>>......>>>.<<.......((.....>>)
).....>>>>>...>>>..>>>>>.>>>>............<<<<<<<..
......>>>>>>>.....<<<<<........>>>>>..>>>.........
...........................<<....>>...............
.<<<<....>>>>..................................<<<
..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<<<<..<<<<<<
<<<........>>>>>>>>>.....>>.>>>......>>>>..>>>>...
.....<<<<<.....<.<<<<.<<.<<<<.>>>>...>>.>.>>>..>..
>>>>>.....<<<<...>>>>>>....>>>>>>>>>>>..>>>.<<<<..
......>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<.....
...>>>..>>>>...<<....>>..<<<<<.....>>>>>...<<<<<..
.<<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>
>>.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<
<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<.
.......>>>>>>>>....>>>>>>>>>...<<.......>>......>>
>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.
....<<...<<<<<<....<<<....<<<..<.<<<...>>>.>..>>>.
.>.>>....>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>....
.......>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>.
..<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<...
.....<...........<<<<<<<<<<..>>>>>>>>>>...........
))).>....>>>>.>.........>>>...>>>>>>><<<<.<<<<<...
.......>>>>.........>>>>>>>>>....>>>>>..<.<<<<<<<<
........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>....
.>>>>>>..............<<<<<<<....................>>
>>>>>....................<<<<<....<<.....>>..>>>>>
....<<..........<<.<<<<<......>>>>...............<
<...>>......>.>>..........<<<<.........>>....>>.>>
...........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ovj Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		K5 C6 G7 R9 R13 L27 P31 R43 R57 G58 T59 R84 K86 A87 N100 R118 R121
Binding residue
(residue number reindexed from 1)		K1 C2 G3 R5 R9 L23 P27 R39 R53 G54 T55 R80 K82 A83 N96 R114 R117
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:0031981 nuclear lumen
GO:0097014 ciliary plasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ovj, PDBe:8ovj, PDBj:8ovj
PDBsum8ovj
PubMed38722744
UniProtQ4QAC5

[Back to BioLiP]