Structure of PDB 8ohz Chain W Binding Site BS01

Receptor Information
>8ohz Chain W (length=204) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFL
GITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFG
PYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCE
SLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLK
MRQD
Ligand information
Ligand IDVOT
InChIInChI=1S/C31H44N6O6/c1-4-21-6-10-23(11-7-21)36-37-24-12-8-22(9-13-24)17-28(41)35-29(20(3)38)31(43)34-26-18-25(39)15-16-32-27(40)14-5-19(2)33-30(26)42/h6-13,19-20,25-26,29,36-39H,4-5,14-18H2,1-3H3,(H,32,40)(H,33,42)(H,34,43)(H,35,41)/t19-,20+,25-,26-,29-/m0/s1
InChIKeyRFGUMPPDEDFOAF-HXNWBPOKSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CCc1ccc(cc1)NNc2ccc(cc2)CC(=O)NC(C(C)O)C(=O)NC3CC(CCNC(=O)CCC(NC3=O)C)O
CACTVS 3.385CCc1ccc(NNc2ccc(CC(=O)N[CH]([CH](C)O)C(=O)N[CH]3C[CH](O)CCNC(=O)CC[CH](C)NC3=O)cc2)cc1
OpenEye OEToolkits 2.0.7CCc1ccc(cc1)NNc2ccc(cc2)CC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]3C[C@H](CCNC(=O)CC[C@@H](NC3=O)C)O
CACTVS 3.385CCc1ccc(NNc2ccc(CC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]3C[C@@H](O)CCNC(=O)CC[C@H](C)NC3=O)cc2)cc1
FormulaC31 H44 N6 O6
Name(2~{S},3~{R})-2-[2-[4-[2-(4-ethylphenyl)hydrazinyl]phenyl]ethanoylamino]-~{N}-[(5~{S},8~{S},10~{S})-5-methyl-10-oxidanyl-2,7-bis(oxidanylidene)-1,6-diazacyclododec-8-yl]-3-oxidanyl-butanamide
ChEMBL
DrugBank
ZINC
PDB chain8ohz Chain V Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ohz Optical Control of Proteasomal Protein Degradation with a Photoswitchable Lipopeptide.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		R98 P101 D124 L125
Binding residue
(residue number reindexed from 1)		R98 P101 D124 L125
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0061133 endopeptidase activator activity
Biological Process
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0019774 proteasome core complex, beta-subunit complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ohz, PDBe:8ohz, PDBj:8ohz
PDBsum8ohz
PubMed38109686
UniProtP25451|PSB3_YEAST Proteasome subunit beta type-3 (Gene Name=PUP3)

[Back to BioLiP]