Structure of PDB 8g4s Chain W Binding Site BS01

Receptor Information
>8g4s Chain W (length=129) Species: 941442 (Giardia intestinalis assemblage A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRINVLRDALKSICNAQRIGKKQVIVRPSSKVIIEFLQLMQKNGYISDFA
VVDNHRSNRIVVNLIGRLNKAGVISPRFDIPANDIEKWVVNLLPSRLFGH
IILTTSQGIMDHIEAQHRQIGGKVIGYFY
Ligand information
>8g4s Chain 2 (length=1441) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagcca
ugcaugcccgcucaccggacgcggcggacggcucaggacaacgguugcac
cccccgcggcgguccuagccggacaccgcuggcaacccggcgccaagacg
ugcgcgcaagggcgggcgcccgggcgagcagcgugacgcagcgacggccc
gcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgag
ggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccug
cgagacggcccgcacauccaaggacggcagcaggcgcggaacuugcccaa
ugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgaggcgggccca
cagcccccgccgcggagccgagggcaagcuggugccagcagccgcgguaa
uuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccgua
guuggccccccgccgccacgaggaaacgggagcgcuccaggcaggcccgu
uggacccgccgcgugggaccgcgcagcgggcgcggcgcgccgcggcagcc
ccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaaca
ggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgcc
ucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccac
cguauucccggccguaaacggugccgccccgcggccggcgcgcgcguccc
gccggccgcccagggaaaccgggaggcuccgggcucuggggggaguaugg
ccgcaaggcugaaacuugaaggcauugacggagggguaccaccagacgug
gagucugcggcucaaucugacccaacgcgcgcaccucaccaggcccggac
gcgcggaggaccgacagccgggcgcgcuuucgcgaucgcgcgggcggugg
ugcauggccgcucccagcccguggcgcgagccgucugcuccauugcgaca
acgagcgagaccccggccgcgggcgccgcgggacggcccgcgcgagcggg
aggacggcggggcgauagcaggucugugaugcccucagacgcccugggcc
gcacgcgcgcuacacuggcggggccagccggcgcccgcgaggacgcgcgg
agcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccagg
aaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccc
cuuguacacaccgcccgucgcuccuaccgacugggcgcggcggcgagcgc
cccggacgcgcgaagggccgcgagcccccgcgccuggaggaaggagaagu
cguaacaagguauccguaggugaaccugcggauggaucccu
...<<<<<.{..(((>>>>>.<<<<<<<<<..<<<<<..<......<<<.
<<<..<<.<<<.........>>>>>......<<........<<<..<<..
<<...<<<<<.........<<.....<<<<<<....>>>>>>......>>
.....<<....<<<...(((..<.....>..>>>...>>.......>.>>
>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>
>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<...
.......>>>>>>.<.<<....>>.>...>>>>>>.........<<<...
.<<<<...>>>>..>>>..>...>>>>>............<<<<<<....
.....>>>>>>.....<<<<<((....<<<<<.....<<..))>>.....
..>>>>>>>>>>..>>>>>>>>>..........<<<[[.....<<<<...
<<<.......<<<.<<<<<<.<.....<<..<<.......>>........
....>>..>..>>>>>..>.>>>..<<.<<<..)))..>>>...>>....
......<<<<<<<.....<<<<..<<..<<<<<.<<<..<.<......>.
>.....>>>.>>>>.>.>>.......<<....>>...>>>>....>>>>.
>>>...>>>...>>>>...<<<<<<<<...<...<<.<.<.....>.>.>
>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.<.....>.>
>>>>>>>>>...<<..]]>>....>>.....>>>.>>>.<<<......<<
<<....>>>>....>>>..)))..}<<<<<.<<<<<<<..<<.<<<<<<.
.<<<.<<<<<<......<<........>>.........<<<<<.<....<
<<<<<......<<<.<<<.......>>>.>>>....>>>>>>...<<.<<
<..<<.<<<<<<....<<.<<<<<<....>>>....<<......>>....
>>>.>>....<<<<..<<<<<<...>>>>>>.....<<<<<....>>>>>
........>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...
>>.>>>>.>>>.....<<<<<<<.......<<<.<<....>>.>>>....
...>>>>>>>......<....<<.<<<<......>>>>.>>....>....
.>>>>>>....<<<<<.<<.......>>.>>>>>......>>...>>>>>
>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.
<<<...........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.
>>...>.....<<<<<<<<<....>>>>>>>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g4s The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function.
Resolution3.14 Å
Binding residue
(original residue number in PDB)		V2 R8 K12 R28 S31 K32 H56 R57 R60 K71 S76 D80 K88 T105 T106 S107 G122 K124
Binding residue
(residue number reindexed from 1)		V1 R7 K11 R27 S30 K31 H55 R56 R59 K70 S75 D79 K87 T104 T105 S106 G121 K123
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g4s, PDBe:8g4s, PDBj:8g4s
PDBsum8g4s
PubMed38242118
UniProtV6TFI0

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