Structure of PDB 8eu9 Chain W Binding Site BS01
Receptor Information
>8eu9 Chain W (length=442) Species:
559292
(Saccharomyces cerevisiae S288C) [
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SLIAAHSHITGLGLDENLQPRPTSEGMVGQLQARRAAGVILKMVQNGTIA
GRAVLVAGPPSTGKTALAMGVSQSLGKDVPFTAIAGSEIFSLELSKTEAL
TQAFRKSIGIKIKEETELIEGEVVEIQIDRSITGGHKQGKLTIKTTDMET
IYELGNKMIDGLTKEKVLAGDVISIDKASGKITKLGRSFARSRDYDAMGA
DTRFVQCPEGELQKRKTVVHTVSLHEIDVINSRTQGFLALFTGDTGEIRS
EVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDEF
APIVMMATNRGVSKTRGTNYKSPHGLPLDLLDRSIIITTKSYNEQEIKTI
LSIRAQEEEVELSSDALDLLTKTGVETSLRYSSNLISVAQQIAMKRKNNT
VEVEDVKRAYLLFLDSARSVKYVQENESQYIDDQGNVQISIA
Ligand information
>8eu9 Chain Z (length=28) Species:
559292
(Saccharomyces cerevisiae S288C) [
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FVKPRRPYNSEGMTRILRRYEEDLFCTF
Receptor-Ligand Complex Structure
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PDB
8eu9
Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility.
Resolution
3.48 Å
Binding residue
(original residue number in PDB)
E139 E142 I143 Q144 I145 D146 R147 H153 Q155 K157 E170 K183 A186 F206 R208
Binding residue
(residue number reindexed from 1)
E122 E125 I126 Q127 I128 D129 R130 H136 Q138 K140 E153 K166 A169 F189 R191
Enzymatic activity
Enzyme Commision number
3.6.4.12
: DNA helicase.
Gene Ontology
Molecular Function
GO:0003678
DNA helicase activity
GO:0004386
helicase activity
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0008094
ATP-dependent activity, acting on DNA
GO:0016787
hydrolase activity
GO:0016887
ATP hydrolysis activity
GO:0043138
3'-5' DNA helicase activity
GO:0043139
5'-3' DNA helicase activity
Biological Process
GO:0000492
box C/D snoRNP assembly
GO:0006281
DNA repair
GO:0006325
chromatin organization
GO:0006338
chromatin remodeling
GO:0006355
regulation of DNA-templated transcription
GO:0006357
regulation of transcription by RNA polymerase II
GO:0006364
rRNA processing
GO:0032508
DNA duplex unwinding
GO:0050821
protein stabilization
Cellular Component
GO:0000785
chromatin
GO:0000812
Swr1 complex
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0031011
Ino80 complex
GO:0035267
NuA4 histone acetyltransferase complex
GO:0097255
R2TP complex
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:8eu9
,
PDBe:8eu9
,
PDBj:8eu9
PDBsum
8eu9
PubMed
37384669
UniProt
Q12464
|RUVB2_YEAST RuvB-like protein 2 (Gene Name=RVB2)
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