Structure of PDB 8byq Chain W Binding Site BS01

Receptor Information
>8byq Chain W (length=187) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPAALKRLAKYVIRGFYGIEHALALDILIRNSCVKEEDMLELLKFDRKQL
RSVLNNLKGDKFIKCRMRVETAADGKTTRHNYYFINYRTLVNVVKYKLDH
MRRRIETDERDSTNRASFKCPVCSSTFTDLEANQLFDPMTGTFRCTFCHT
EVEEDESAMPKKDARTLLARFNEQIEPIYALLRETED
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8byq Chain W Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8byq Structural basis of transcription reduction by a promoter-proximal +1 nucleosome.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		C129 C132 C154 C157
Binding residue
(residue number reindexed from 1)		C120 C123 C145 C148
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006367 transcription initiation at RNA polymerase II promoter

View graph for
Biological Process
External links
PDB RCSB:8byq, PDBe:8byq, PDBj:8byq
PDBsum8byq
PubMed37148879
UniProtP29083|T2EA_HUMAN General transcription factor IIE subunit 1 (Gene Name=GTF2E1)

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