Structure of PDB 7pwg Chain W Binding Site BS01

Receptor Information
>7pwg Chain W (length=65) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VTTNQCSYSGRKILPGYGKRMSRHDKVLLIFLNRKASVHYLNKWNPRKIR
WTLASRRARGKEVIV
Ligand information
>7pwg Chain 1 (length=2450) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cggcccgaggcggcgggggcgacgggcggaacuuaagcauaucaguacgc
cccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcggga
ggagcccgccccgaaggcgcgcugugggcgccgcgagggggcccgagggc
cccgcccgagagggugcaagccccguacggcgggcgaguagcgcugcuug
agcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgcccc
gggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgccc
ggccgcucaaaagaccugaacccggccggcgccggcccgccggccccguc
ucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggccccg
cggcggagcgagcgcgagacgccccgggcccgccgcgccccugcgggcgu
gcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugccc
ggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcug
acgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucga
accgccugguagcugguugccuccgaaaugucucccaggacagccgccgc
ccgcaguugcggcccguagagcgcuggccggcggccgccccccaaacucc
gaagggccgcgccgccccgcccuggccugggcggggcgggcgaaugcggg
cggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgaucc
ggacgccgggccagggugcgccgccggggccggaacggcgucggccgcgg
ccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgc
cgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgc
gcaggccccgccggaccggccucuggugcagaucucggcagcaguagcgc
uacuccgcgccccggaggacugagggggagacggguuccgcggcgccugc
aucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaagg
ggcgugcccgcccgucgaacggggagccggcggagacuccggcaggcgcg
ggcggagacgcgccccccggcgacgcgcacggggaccgcggcgggcggcg
ccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggg
gggcccgggggcggaccgcgcguccccggccgccccugaaaagccggggg
gcccgcgcgccguaccgaccgcacaggacuccggggucagcagccucuag
cgcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccu
cgggaaaaggaguggcucugacggggucagaacuggaacggacgcgggga
ucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcu
ggcgcgacgugauuucugcccagugccagaccgucaccgugaagcgaucc
gccgaagcccugguaaacggcgggaguaaugacucucuuaagguagccaa
augccucgucgggcaauuuccgacggcaugaauggaccaacgaggauccc
acugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgag
ggccggccagcggggcaagaagacccuuuugagcuugacuccagcccggg
ccuguggggcggggccgccccgcucacccggucgcgcggggacccgcccg
ggcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcg
ucccacggcgggcucagcgaggacccucccgcggagcagaagggcacaag
cccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggcc
uaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguu
accacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggc
uuuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgc
ggaagcgucggauuguucacccguucaagggaucgugagcuggguuuaga
ccgucgugagacgguuaguuuuacccuacuggccccggggccagagcacg
gcgggccaguacggaggaacgcccgccgcgggcgcccagccccgcgguug
cccgccggggcaggaccgcgcgcccgggcccgggggccuggcgcugccgc
cucuaaagcgccaccccccccuccggccccgccgcccgcgccccagcccc
gugcccccugcccgaggcggcccccgcccgggaggaccacccggcgcggc
gccccuguacggcgagggcgcguucgcccggggggcgcgccgcgggcgcg
......................<<<<<<.....<<....>>......>>>
>>.>.........<<....>>..<<<<<....<<.....>>.....>>>>
>..[[[...<<<<...........>>>><<<<.....<<<<<......>>
>>>((......<<<.....))>>>....>>>>........<<<<<<<...
.....>>>>>>>...(((((..<<<<<<)))))..]]]............
......................<<....>>................<<<.
>>>...........................<<<<<<..>>>>>>.<<<<.
.......>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<.>>>.
.>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>
>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<
<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<
<........>>>>.>>>....>>>>>>>>>...<<.......>>......
>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<
<<<<<.<<<<<<<<<...<<<...<<<..<<<<..>>>>..>>>..>>.>
...>>>>>>>.<<<<<<<<<<<......>>>>>>>>>>>...>>>>>>>>
>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>
>...<<<<<<<..<<<<(((...<<<<<<<.....<<<.<<<<<<<..>>
>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<
<<....>>>>>....>>>>>><<<<<<<<<<...<<......<<<<<.<<
....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>.<<.....<<..
..<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<...<...
....>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<
<<<..>>>>...>>.>....>>...<<<<<........>>>>>))<<<<<
<<<<....>>><<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<....
.....>>>>>....<<<<<<...<<<<<<....<<.....>>......>>
>>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>
>>>>>>>>.>>>..>>..<<.....>>.>>>>.<<<<.....>>>>..>>
....<<<<....<<<<<<<<.<<.........<.....<<<<<....<<.
.>>.....>>>>><<.<<<<<<...>>>>>>.>>............<<<<
<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>...
...>>>>>>>...<<..<<<..<<<<<<<...<<....<<<.<....>.>
>>....>>.>>>>>..>>>>><<<<<<....>>>>>>........<....
.......<<<<<<.....>>>>>>....>.....>>....>>.>>>>>>>
..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>
>...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<
<..<<<<<<<<<..>>>>>>>>>...<<<<......>>>>.....>>>>>
>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>.
.<<...<<<<<<<...<.<<<<..>>>>.>.....<<...(((>>....>
>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))
).......(((((.(((((.>>>>>>))))))))))..........]]]]
..}}.}}}.......<<.<.<.<<<<<<...<<.......>>...>>>>>
>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>
>>..>>>.<<<.........>>>....>>>>>..>...>>>.>>....<<
<<<<<....>>>>>>>........}}}.))))))..<<<<<<.<<<..<<
<<<<<<..............>>>>>>>><<<<<...<.<....<<<<<<<
<<<....>>>>>..>>>>>....>.>.>>>>>.<<<...<<<<<<.....
......>>>>>>...>>>..>>>.>>>>>>...<.<<<............
.................>>>.>...<<.<<<<.......>>>>..<<<<<
<<<<<<....<<<<<<.<..>.>>>>>>...>>>>.>>>>>>>....>>.
Receptor-Ligand Complex Structure
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PDB7pwg Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Resolution2.75 Å
Binding residue
(original residue number in PDB)
G17 G19 K20 R35 K36 K44 W45 N46 K49 R51 W52 R57 K62
Binding residue
(residue number reindexed from 1)
G16 G18 K19 R34 K35 K43 W44 N45 K48 R50 W51 R56 K61
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005730 nucleolus
GO:0005840 ribosome

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7pwg, PDBe:7pwg, PDBj:7pwg
PDBsum7pwg
PubMed35100413
UniProtA8BRH7

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