Structure of PDB 7nwg Chain W Binding Site BS01

Receptor Information
>7nwg Chain W (length=63) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKVELCSFSGYKIYPGHGRRYARTDGKVFQFLNAKCESAFLSKRNPRQIN
WTVLYRRKHKKGQ
Ligand information
>7nwg Chain 51 (length=3626) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaau
guggcguacggaagacccacuccccggcgccggggggcccaaguccuucu
gaucgaggcccagcccguggacggugugaggccgguagcggcccccggcg
cgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaa
agcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauag
ucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguuc
aagagggcgugaaaccguuaagagguaaacgggugggguccgcgcagucc
gcccggaggauucaacccggcggcgcgguccggccgugccggcggggcgg
aucucccgcucccgucggcgggggaccgccccccggccggcgaccggccg
ccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggac
ggcugggaaggccccggcggggaagguggcccgggggccccggguguuac
agccccgccccggcagcagcagcucgccgaaucccggggccgagggagcg
agacccgugcgccgcgcucuccccccucgggggggccgggccaccccucc
cacggcgcgaccgcucucccacccggggggcggggcggacuguccccagu
gcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggc
cacgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgu
cuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacg
aaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggcc
gaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggccc
gucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggac
ccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucu
gguggagguccguagcgguccugacgugcgaaucggucguccgaccuggg
uauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaa
guuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcga
augauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuu
aaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcg
agugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaa
ccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaa
aagguguugguugauauagacagcaggaugguggccauggaagucggaau
ccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaa
auggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucg
gcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggag
ggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccg
ccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuu
gaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggu
cagucgguccugagagaugggcgagcgccguuccgaagggacgggcgaug
gccuccguugcccucagccgaucgaaagggagucggguucagauccccga
auccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcg
accgaucccggagaagccggcgggagccccggggagaguucucuuuucuu
ugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccg
ugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcugg
cccuugaaaauccgggggagaggguguaaaucucgcgccgggccguaccc
auauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaa
uguagguaagggaagucggcaagccggauccguaacuucgggauaaggau
uggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaau
ccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguug
acgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauuc
aaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagc
caaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagau
ucccacugucccuaccuacuauccagcgaaaccacagccaagggaacggg
cuuggcggaaucagcggggaaagaagacccuguugagcuugacucuaguc
uggcacggugaagagacaugagagguguagaauaagugggaggcccgggc
cgccggugaaauaccacuacucugaucguuuuuucacugacccggugagg
cgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggcc
gggcgcgacccgcuccggggacagugccagguggggaguuugacuggggc
gguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggag
gacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugau
uuucaguacgaauacagaccgugaaagcggggccucacgauccuucugac
cuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacu
ggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucga
ugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauug
uucacccacuaauagggaacgugagcuggguuuagaccgucgugagacag
guuaguuuuacccuacugaugauguguuguugccaugguaauccugcuca
guacgagaggaaccgcagguucagacauuugguguaugugcuuggcugag
gagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucu
aagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggc
cucggauagccggucccccgcccgggguccggugcggagagcccuucguc
ccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgca
ccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcu
ucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaa
agucagcccucgacacaaggguuugu
.........................<<<<<<.....<......>......
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....>>>>.....((......<<<.....))>>>...>.>>>>>>>...>
>>..>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>..
...(((((..<<<<<<)))))..]]]........................
..........<<....>>...............<<<......>>>.....
.............................<<<<<<<<..<<<.<....<<
<<<<<<.........<<<<<<<<<<....<<<<<<<.<<<...<<<<<<<
.<<<<<<<<<......>>>>>>>>>>>>>>>>..>>>>>>>...>>>.>>
>>>>>>>>..........>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<
<<<.........<..<<<<<<<......<<<<<<<<.>>>>>>>>.....
..>>>>>>>...>............>>>>...>>>>>>>>>>.....<..
.......>.........<...<<<<<<..>>>>>>.....<<..<<<.<<
<<<<<<<<<<<<<<....<..<<..>>.>.<<<<<<<.<<........>>
.>>>>>>>.>>>.>>>>>>>>>>.>>>...>>>.............>>..
.......>.........>>.>>>>>....>>>>...>>>>>>>>...<<<
........>>>.<<<<<<....<<<.<<<<<<<<<..<<<...<<<<...
..>>>>.....>>>...<<....>>...<<<<<.<<<<..>>>>.>>>>>
..<<<<<...<<<..<<........[...>>..>>>....>>>>>.<<<<
<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>.>>>..<
<.<..<<<<<<<.....<<<<<<<<<..<<<....<.<<<<......>>>
>.>.....>>>...<<<..<..<<........>>.>.>>>....>>>>>>
>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<...
.<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<....<<<...
.<<<....<<<..<<<<.............>>>>>>>....>>>...>>>
....>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>
>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......
>>>...<<<<<<<...<<<(((.......<<<<<.....<<.........
.<<<.<<<..<<<.........<<<.........<<.........>>...
............<<......>>.....>>>.....>>>..>>>>>>....
......))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.....
................]................>>>>>>>>>....>>>>
>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>
>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>
>>>.<<<......<<<<.<<...<<<<<<...<<.....>>.>>>>>>..
..((<<<<<<...<<....<<<....>>>.............<<<<<<<<
<...>>>>>>>>>........>>....>>>..<<<<<........>>>>>
))<<<<....<<<......<<<<<......>>>>>....<<<....>>>.
......<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>
>.....<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>.
.>>>>......<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>
>.........>>>>>>.................>>>.>>>>.>>>..>>.
....<<......>>>>>>..<<<<.....>>>>..>>>....<<<<....
.<<<<<<<.<<...............<<<<<...............>>>>
><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<
<<<..<<...........>>..<<<<<<<....<<<<.....>>>>....
..>>>>>>>....<..<<<..<<<<<<....<<<.....<<<<....>>>
>.....>>>.>>>>..>>>>>...<<.........>>...........<.
..........<<<<<.......>>>>>.....>.....>.....>>.>>>
>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<.........
.>>>>.....[[[[..{{{.{{......[[[[....[[[..<<<<..<<<
<<<<<<.<<<<<<....<<.<<<<..........<<<.<...<<<..>>>
.............>.>>>.>>>>.>>.....>>>>>>...<<<<<.....
<<<<.....<........>..................<<<<<<<<..>>>
>>>>>...>>>>..>>>>>....>>>>>>>>>...>>>>...<<<.....
>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<
<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<
<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..
(((..>>>>>>.)))))))))..........]]].....]]]].......
<<.<.<.<<<<<<...<.........>...>>>>>>...>>.>.>.....
..<<<<<.<<<<<...<...<<<<<......>>>>>.....>.<<<....
.....>>>......>>>>..>...>>>.>>....<<<.<<<....>>>..
>>>....}}..}}}.]]]]......<<<<<<....<<<..<.<<<<<...
..............>>>>>.><<<<.....<<<....<<..<.<<<.}}}
..>>>....>.>>...>>>....>>>><<<<....<<<<...........
..>>>>....>>>>.>>>.....>>>>>>.<<<<<<<..<<<.....<<<
........<<<<<<..<<<<..>>>>>.>>>>>.......>>>...<<<.
.<<<<....<<<.<<<<<........>>>>>..>>>...>>>>..>>>..
.............>>>..>>.>>>>>.<<<<<.<.............>..
..<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....
>>....>>>>.>>>.>>..>>>>>..
Receptor-Ligand Complex Structure
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PDB7nwg Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Resolution3.8 Å
Binding residue
(original residue number in PDB)
R19 K35 R44 N50 W51 R56 K61
Binding residue
(residue number reindexed from 1)
R19 K35 R44 N50 W51 R56 K61
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:7nwg, PDBe:7nwg, PDBj:7nwg
PDBsum7nwg
PubMed34157102
UniProtA0A061I3X8

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