Structure of PDB 7nvy Chain W Binding Site BS01

Receptor Information
>7nvy Chain W (length=202) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPAALKRLAKYVIRGFYGIEHALALDILIRNSCVKEEDMLELLKFDRKQL
RSVLNNLKGDKFIKCRMRVETAADGKTTRHNYYFINYRTLVNVVKYKLDH
MRRRIETDERDSTNRASFKCPVCSSTFTDLEANQLFDPMTGTFRCTFCHT
EVEEDESAMPKKDARTLLARFNEQIEPIYALLRETEDAKERPIWLRESTV
QG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7nvy Chain W Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7nvy Structures of mammalian RNA polymerase II pre-initiation complexes.
Resolution7.3 Å
Binding residue
(original residue number in PDB)		C129 C132 C154 C157
Binding residue
(residue number reindexed from 1)		C120 C123 C145 C148
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0046872 metal ion binding
Biological Process
GO:0001113 transcription open complex formation at RNA polymerase II promoter
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005673 transcription factor TFIIE complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nvy, PDBe:7nvy, PDBj:7nvy
PDBsum7nvy
PubMed33902107
UniProtP29083|T2EA_HUMAN General transcription factor IIE subunit 1 (Gene Name=GTF2E1)

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