Structure of PDB 6ryr Chain W Binding Site BS01

Receptor Information
>6ryr Chain W (length=708) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTC
PALKGKVQKILIWKWGPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFR
NYQRKNDMDEPPSEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRIL
NHSVDKKGHVHYLIKWRDLPYDQASWESEDVEIQDYDLFKQSYWNHRELM
TVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMG
LGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVV
TYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYEL
ITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTP
LQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHM
LRRLKADVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGN
QVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLL
LQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNM
RQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDI
QAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRAAAA
AAAAAAAA
Ligand information
>6ryr Chain I (length=149) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcagaatcccggtgccgaggccgctcaattggtcgtagacagctctagc
accgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggg
gattactccctagtctccaggcacgtgtcagatatatacatcgataggc
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6ryr Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R572 R576 R813 K833 E853 I857 M1075 T1076 G1098 R1105 S1125 R1127 A1128
Binding residue
(residue number reindexed from 1)		R100 R104 R309 K329 E349 I353 M571 T572 G594 R601 S621 R623 A624
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006338 chromatin remodeling

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6ryr, PDBe:6ryr, PDBj:6ryr
PDBsum6ryr
PubMed32543371
UniProtQ14839|CHD4_HUMAN Chromodomain-helicase-DNA-binding protein 4 (Gene Name=CHD4)

[Back to BioLiP]