Structure of PDB 6i9r Chain W Binding Site BS01

Receptor Information
>6i9r Chain W (length=111) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSKNLGGKSSGRRQGIKKMEGHYVHAGNIIATQRHFRWHPGAHVGVGKNK
CLYALEEGIVRYTKEVYVPHPRNTEAVDLITRLPKGAVLYKTFVHVVPAK
PEGTFKLVAML
Ligand information
>6i9r Chain A (length=1501) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagcc
aaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgc
aauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaa
uauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaa
uaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcua
ccuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggga
agauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguu
guccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuaa
auccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggac
acuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguag
gccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaa
ucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucac
ccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccucc
gcauaagccugcgucagauaacacaacugacaauuaacagcccaauaucu
acaaucaaccaacaagucauuauuacccucacugucaacccaacacaggc
augcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuua
ccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagagg
caccgccugcccagugacacauguuuaacggccgcgguacccuaaccgug
caaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggc
uccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugc
ccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcu
uuaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguu
ggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacu
ucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaac
aaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaac
aauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagc
cgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugag
uucagaccggaguaauccaggucgguuucuaucuacuuauuccucccugu
acgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccgu
aaaugauaucaucucaacuuaguauacccacacccacccaagaacagggu
u
<<.......<<<<.....................................
<......>.........<.....<<.....>>....>........>>.>>
.............<<....>>......................>>.....
.......<<<.......>>>...<.<........>.>.<<<<<<......
...<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<
<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>.
...>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..
<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<.......
.>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>
...<<<......>>>....<<<.<<<...<..............<....<
<<.........>>>....>.......<<<......>>>............
...............>...>>>>>>........>>>>>>...<<<<<...
...>>>>>.........>>>>>><......<<..<<<....>>><<<<..
<<<<........<<<<<.........>>>>>......<<<...<<<<...
....................>>>>.......>>>.....<<......>>.
>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<
<<<<<..<<<.........>>>...<<<<<<.............>>>>>>
....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>
........<...........<<<<<<.....>>>>>>.....>....>>>
....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<
<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<
..<<<<..<<<<<<<<...............>>>>>>>>.>>>>..<<<<
.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<
.....>>>>..>>>....>>.........<<<....>>>...........
.>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...
>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<.....
.>>>>>>...>>.<<<<.......>>>>.....>>>>>..>...>>>.>>
....<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<.....
............>>>.>>><<<<<...<<<....>>>.>>>>>......<
<<................>>>..............<<<<.......>>>>
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6i9r Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		S38 N41 G44 S46 S47 G48 R49 R50 K54 M56 E57 H59 A63 G64 N65 I66 R71 R74 G84 K85 N86 C88 Y90 L92 Y99 K101
Binding residue
(residue number reindexed from 1)		S1 N4 G7 S9 S10 G11 R12 R13 K17 M19 E20 H22 A26 G27 N28 I29 R34 R37 G47 K48 N49 C51 Y53 L55 Y62 K64
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6i9r, PDBe:6i9r, PDBj:6i9r
PDBsum6i9r
PubMed33910005
UniProtQ9P0M9|RM27_HUMAN Large ribosomal subunit protein bL27m (Gene Name=MRPL27)

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