Structure of PDB 6bcu Chain W Binding Site BS01

Receptor Information
>6bcu Chain W (length=1052) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLN
VGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRA
RYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVF
NKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQEL
EVSMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKC
VSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLF
QKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWD
LAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQL
PIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSS
ARELRPLLVFIWAKILAVDSSCQADLVKDNGHKYFLSVLADPYMPAEHRT
MTAFILAVIVNSYHTGQEACLQGNLIAICLEQLNDPHPLLRQWVAICLGR
IWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALGTFVGNSAER
TDHSTTIDHNVAMMLAQLVSDGSPMVRKELVVALSHLVVQYESNFCTVAL
QFISVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIAYKFISATVQTGFCD
WSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGIT
RLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFH
NGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTA
WQGLSAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCV
TSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASL
QKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTALDIHPQADLIA
CGSVNQFTAIYNSSGELINNIKYAISCLAFHPHWPHLAVGSNDYYISVYS
VE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6bcu Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		R305 F337 R338 L437 Q438 L440 L441 R446 Y475 K478
Binding residue
(residue number reindexed from 1)		R272 F304 R305 L404 Q405 L407 L408 R413 Y442 K445
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0030291 protein serine/threonine kinase inhibitor activity
GO:0030295 protein kinase activator activity
GO:0030674 protein-macromolecule adaptor activity
GO:0031267 small GTPase binding
GO:0044877 protein-containing complex binding
GO:0071889 14-3-3 protein binding
GO:0140767 enzyme-substrate adaptor activity
Biological Process
GO:0001558 regulation of cell growth
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006974 DNA damage response
GO:0008361 regulation of cell size
GO:0009267 cellular response to starvation
GO:0009410 response to xenobiotic stimulus
GO:0010506 regulation of autophagy
GO:0010507 negative regulation of autophagy
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0030307 positive regulation of cell growth
GO:0031669 cellular response to nutrient levels
GO:0031929 TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035176 social behavior
GO:0038202 TORC1 signaling
GO:0045672 positive regulation of osteoclast differentiation
GO:0045821 positive regulation of glycolytic process
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:0046889 positive regulation of lipid biosynthetic process
GO:0071230 cellular response to amino acid stimulus
GO:0071233 cellular response to L-leucine
GO:0071333 cellular response to glucose stimulus
GO:0071456 cellular response to hypoxia
GO:0071470 cellular response to osmotic stress
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1901331 positive regulation of odontoblast differentiation
GO:1905857 positive regulation of pentose-phosphate shunt
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0030425 dendrite
GO:0031931 TORC1 complex
GO:0043025 neuronal cell body

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6bcu, PDBe:6bcu, PDBj:6bcu
PDBsum6bcu
PubMed29236692
UniProtQ8N122|RPTOR_HUMAN Regulatory-associated protein of mTOR (Gene Name=RPTOR)

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