Structure of PDB 5xxu Chain W Binding Site BS01

Receptor Information
>5xxu Chain W (length=129) Species: 5811 (Toxoplasma gondii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRMNVLADCLKTLVNAEKRGRRQVLIRPSSKVIIKFLQCMQRRGYIGDFE
IVDDHRAGKIVIELLGRINKCGVISPRFDIQVDKIEQFCSNLLPSRQFGH
LVLTTAYGIMDHEEARRKHTGGKILGYFF
Ligand information
>5xxu Chain 2 (length=1619) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaccugguugauccugccaguagucauaugcuugucuuaaagauuaagcc
augcaugucuaaguauaagcuuuuauacggcuaaacugcgaauggcucau
uaaaacaguuauaguuuauuugauggucuacauggauaaccgugguaauu
cuauggcuaauaccugcgcacaguguuuauuagauacagaaccaagguga
uucauaguaaccgaacggaucgcgcugcgacggaucauucaaguuucuga
ccuaucagcuuucgacgguacuguaauggacuaccguggcagugacgggu
aacggggaauuaggguucgauuccggagagggagccugagaaacggcuac
cacaucuaaggaaggcagcaggcgcgcaaauuacccaauccugauucagg
gagguagugacaagaaauaacaaccuggagugauuggaugauaggaaucc
aaaccccuuucagaguaacaauuggagggcaagucuggugccagcagccg
cgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaag
cucguaguuggauuucugcuggaaggccaauucuagcauccuucuggacu
uuuacuuugagaaaauuagaguguuucaagcaggcuugucgccuugaaua
cucagcauggaauaauaagauuucggcccuauuuugguuucuaggacuga
aguaaugauuaauagggacgguugggggcauucguauuuaacugucagag
gugaaauucuuagauuuguuaaagacgaacuacugcgaaagcauuugcca
aagauguuuucauuaaucaagaacgaaaguuaggggcucgaagacgauca
gauaccgucguagucuuaaccauaaacuaugccgacuagagauaggaaaa
cgucaugacuucuccugcaccuuaugagaaaccaaagucuuuggguucug
gggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggca
ccaccaggcguggagccugcggcuuaauuugacucaacacggggaaacuc
accagguccagacauaggaauugacagauugauagcucuuucuugauucu
augggugguggugcauggccguucuuaguugguggagugauuugucuggu
uaauuccguuaacgaacgagaccuuaaccugcuaaauaggaucaggaacu
ucguguucuuguaucacuucuuagagggacuuugcgugucuaacgcaagg
aaguuugaggcaauaacaggucugugaugcccuuagauguucugggcugc
acgcgcgcuacacugaugcauccaacgaguccuuggccgauaggucuagg
uaaucuugugaguaugcaucgugauggggauagauuauugcaauuauuaa
ucuucaacgaggaaugccuaguaggcgcaagucagcacguugcgccgauu
acgucccugcccuuuguacacaccgcccgucgcuccuaccgauugagugu
uccggugaauuauucggaccguuuuguggcccgaaaugggaaguuuugug
aaccuuaacacuuagaggaaggagaagucguaacaagguuuccguaggug
aaccugcggaaggaucauu
...<<<<<.{.[[[[>>>>><<<..<<<<<<...<<<<..<......<<<
.<<<..<<....<<....<<<.......>>>...>>.>>......<<..<
.....<<<..<<..<<....<<<<.........<.....<<<<<<.....
>>>>>>......>.........<<..<<<<<<.......(((((......
....>>>>>>....>>...<<<<...>>>>...>>>>...>>>>..>>>.
<<<....<<<....<<<<<<...........>>>>>>>>>......>>>.
..<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>
>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>
..>>>..>...>>>>.....<<<.<....>...>>>.....<.<<<....
.......>>>.>.........<<<<<((....<.<<<<.....<<..))>
>.......>>>>>>>>>>..>>>>>>.>>>.........<<<[[.....<
.<<...<<<.<<.....<<<<<<<......>>>>>>>.....<...>...
.<<<<<.<<.......<<...<.......>..<<<.....>>>.....>>
.....>>.>>..>>>.....<<<<<<.<<<....)))))...>>>.>>>>
>>......>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<
......>>>......>.>>>>>.>.>>.......<<....>>...>>>>.
..>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<..
...>.>>>>...>>>>>>>>..........<<<.<<.<<.<.<<<<<.<<
.<<<..>>>>>.>>>>>..>>>...<...]].>...>>.....>>>.>>>
.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<
..<<.<<<<<<..<<<.<<<<<<......<<........>>.........
.<<<<<.<....<<<<<......<..<<........>>..>.......>>
>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<.
.....>>>...>>.>>>....<<<<<.<<..<<<<..<<....<<<<<<.
....>>>>>>......>>..>>>>.>>....<<<<<<.....>>>>>.>.
.....>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>
.>>>>.>>>.....<<<<<<<......<<.<<<.<<<<....>>>>.>>>
....>>.......>>>>>>>...........<<<<<<..........>>>
>>>..........>>>>>>....<<<<<<<.........>>>>>>>....
..>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<
<..<<<..<<.<..<...<<<<<<<<.....>>>>>>>>...>..>.>>.
.>>>..>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<<.
.>>>>>>>>>>........
Receptor-Ligand Complex Structure
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PDB5xxu Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Resolution3.35 Å
Binding residue
(original residue number in PDB)		V2 M4 N5 V6 A8 D9 T13 N16 R20 R28 S31 K32 R57 K71 V74 I75 S76 R78 D80 Q82 V83 Q88 T105 T106 A107 Y108 R118 K119 H120 G122 K124 Y128 F130
Binding residue
(residue number reindexed from 1)		V1 M3 N4 V5 A7 D8 T12 N15 R19 R27 S30 K31 R56 K70 V73 I74 S75 R77 D79 Q81 V82 Q87 T104 T105 A106 Y107 R117 K118 H119 G121 K123 Y127 F129
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xxu, PDBe:5xxu, PDBj:5xxu
PDBsum5xxu
PubMed28809395
UniProtA0A125YJX3

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