Structure of PDB 2j37 Chain W Binding Site BS01

Receptor Information
>2j37 Chain W (length=479) Species: 9616 (Canis sp.) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVK
SAIDLEEMASGLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGNVIMFVGL
QGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPF
YGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVA
NAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGA
LSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLIDKVNE
LKLDDNEALIEKLKHGQFTLRDMYEQFQNIMKMGPFSQILGMIPGFGTDF
MSKGNEQESMARLKKLMTIMDSMNDQELDSTDGAKVFSKQPGRIQRVARG
SGVSTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVSQSQMAKLN
QQMAKMMDPRVLHHMGGMAGLQSMMRQFQ
Ligand information
>2j37 Chain A (length=128) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gacacuaaguucggcaucaauauggugaccucccgggagcgggggaccac
cagguugccuaaggaggggugaaccggcccaggucggaaacggagcaggu
caaaacucccgugcugaucaguaguguc
<<<<<<<.<.<<<<<<<<<<<.<<<<<..<<<<<<....>>>>>>..>>>
>>.>>>>........<<<<<.....<<<<..<.<<<....>>>..>.>>>
>...>>>>>.>>>>>>>.>..>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2j37 Following the signal sequence from ribosomal tunnel exit to signal recognition particle.
Resolution8.7 Å
Binding residue
(original residue number in PDB)		T377 D380 S381 N383 R402 R405 R408 G409 S410 G411
Binding residue
(residue number reindexed from 1)		T368 D371 S372 N374 R393 R396 R399 G400 S401 G402
Enzymatic activity
Enzyme Commision number 3.6.5.4: signal-recognition-particle GTPase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0008312 7S RNA binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0019003 GDP binding
GO:0030942 endoplasmic reticulum signal peptide binding
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0030593 neutrophil chemotaxis
GO:0030851 granulocyte differentiation
GO:0031017 exocrine pancreas development
GO:0045047 protein targeting to ER
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0048500 signal recognition particle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2j37, PDBe:2j37, PDBj:2j37
PDBsum2j37
PubMed17086193
UniProtP61010|SRP54_CANLF Signal recognition particle subunit SRP54 (Gene Name=SRP54)

[Back to BioLiP]