Structure of PDB 1iru Chain W Binding Site BS01

Receptor Information

>1iru Chain W (length=220) Species: 9913 (Bos taurus)

TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAA
DTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYRGYIGAALVL
GGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEE
AKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLG
RYRCEKGTTAVLTEKITPLE

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1iru Chain W Residue 406

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1iru The structure of the mammalian 20S proteasome at 2.75 A resolution.
• Resolution: 2.75 Å
• Binding residue (original residue number in PDB): I163 D166 L167 S169
• Binding residue (residue number reindexed from 1): I163 D166 L167 S169
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): T1 D17 R19 K33 G47 S129 D166 S169
• Catalytic site (residue number reindexed from 1): T1 D17 R19 K33 G47 S129 D166 S169
• Enzyme Commision number: 3.4.25.1: proteasome endopeptidase complex.

Gene Ontology

Molecular Function

• GO:0004298 threonine-type endopeptidase activity

Biological Process

• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0005839 proteasome core complex

External links

• PDB: RCSB:1iru, PDBe:1iru, PDBj:1iru
• PDBsum: 1iru
• PubMed: 12015144
• UniProt: Q2TBP0|PSB7_BOVIN Proteasome subunit beta type-7 (Gene Name=PSMB7)