Structure of PDB 1g0u Chain W Binding Site BS01

Receptor Information

>1g0u Chain W (length=204) Species: 4932 (Saccharomyces cerevisiae)

SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFL
GITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFG
PYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCE
SLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLK
MRQD

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1g0u Chain W Residue 9015

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1g0u A gated channel into the proteasome core particle.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): A163 D166 S169
• Binding residue (residue number reindexed from 1): A174 D177 S180
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.99.46: Transferred entry: 3.4.25.1.

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0061133 endopeptidase activator activity

Biological Process

• GO:0010499 proteasomal ubiquitin-independent protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0000502 proteasome complex
• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005839 proteasome core complex
• GO:0019774 proteasome core complex, beta-subunit complex

External links

• PDB: RCSB:1g0u, PDBe:1g0u, PDBj:1g0u
• PDBsum: 1g0u
• PubMed: 11062564
• UniProt: P25451|PSB3_YEAST Proteasome subunit beta type-3 (Gene Name=PUP3)