Structure of PDB 8esz Chain V1 Binding Site BS01

Receptor Information
>8esz Chain V1 (length=438) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTPPPQTKTKFGPLADEDRIFTNLYGRHDWRLKGALKRGDWYKTKEIVLK
GADWIVNEIKTSGLRGRGGAGFPSGMKWSFMNKPGDGRPKYLVVNADEGE
PGTCKDREIMRHDPHKLVEGCLIAGRAMGAQAAYIYIRGEFYNEASNMQL
AIAEAYQAGLIGKNACGTGYDFDVFMHRGAGAYICGEETALIESLEGKQG
KPRLKPPFPADVGVFGCPTTVTNVETVAVAPTICRRGGVWFASFGRTRNS
GTKLFNISGHVNRPCTVEEEMSIPLKELIERHCGGVTGGWDNLLGVIPGG
SSTPIIPKNVCDDVIMDFDGLIAAQTSLGTAAIIVMDKSTDVIKAIARLI
SFYKHESCGQCTPCREGIGWMNKIMTRFVKGDAQPAEIDMLWEISKQIEG
HTICALGDGAAWPVQGLIRHFRPEIEKRMQLHAKRVSN
Ligand information
>8esz Chain V3 (length=27) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAAAAAAAAAAAAAAAAAAAAAAAAAA
Receptor-Ligand Complex Structure
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PDB8esz Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R147 Y178 N179 Y192 K199 D209
Binding residue
(residue number reindexed from 1)		R111 Y142 N143 Y156 K163 D173
Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Gene Ontology
Molecular Function
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0010181 FMN binding
GO:0046872 metal ion binding
GO:0051287 NAD binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045271 respiratory chain complex I

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8esz, PDBe:8esz, PDBj:8esz
PDBsum8esz
PubMed36952377
UniProtQ9VMI3

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