Structure of PDB 6hcf Chain V1 Binding Site BS01

Receptor Information
>6hcf Chain V1 (length=100) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTRK
TPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTIA
Ligand information
>6hcf Chain A1 (length=1732) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucagaucaaaaccaacccggucaggcggcuuuggugac
ucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucga
acgucugcccuaucaacuuucgaugguagucgccgugccuaccaugguga
ccacgggugacggggaaucaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacuccc
gacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggc
ccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauugg
agggcaagucuggugccagcagccgcgguaauuccagcuccaauagcgua
uauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggc
cguccccugccucucggcgccccggggcccgaagcguuuacuuugaaaaa
auuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaaugg
aauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauu
aagagggacggccgggggcauucguauugcgccgcuagaggugaaauucu
uggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuu
cauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucg
uaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauuccc
augacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggg
gaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccac
caggaguggagccugcggcuuaauuugacucaacacgggaaaccucaccc
ggcccggacacggacaggauugacagauugauagcucuuucucgauuccg
ugggugguggugcauggccguucuuaguugguggagcgauuugucugguu
aauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccc
ggucggcguaacuucuuagagggacaaguggcguucagccacccgagauu
gagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcg
cuacacugacuggcucagcgugugccuacccuacgccggcaggcgcgggu
aacccguugaaccccauucgugauggggaucggggauugcaauuauuccc
caugaacgaggaauucccaguaagugcgggucauaagcuugcguugauua
agucccugcccuuuguacacaccgcccgucgcuacuaccgauuggauggu
uuagugaggcccucggaucggccccgccggggugcccuggcggagcgcug
agaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagg
uuuccguaggugaaccugcggaaggaucauua
...<<<<<.{.((((>>>>><<<.<<<<<<.....<<..<......<<<.
<<<...<....<<....<<..........>>...>>.>.......<<...
.....<<<.<....<<....<<<<..........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<......((((.((.<<..<...>.>>....<.....
.>..>>>>>......>>...<<<<..<<<.>>>.>>>>..>.>>>...>>
..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.......
...>>>.>>...<<....>>.....>>>>>>.........<<<....<<<
.....>>>..>>>..>...>>.......<<<<<<<<<.<<......>>..
>>>>>>.>>>......<<..<...........>..>>.........<<<<
<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>
>.>>>.........<..[[.....<.<<...<<<.<<....<<<.<<<..
>>>.>>>...........<.<<<.>>>>.........<<<<<<.<.....
..<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>...
.......<<.<<<<<<<......)).))))..>>>>>>>.>>......>>
....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>.
.....>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>
>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>.
..>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<......
..>>>>>>>>>.>..>>>...<<..]]>>...>>.....>>>...>.<<<
......<<<......>>>....>>>..)))).}<<<<<.<<<<<<<...<
..<<<<<..<<<.<<<<<<......<<........>>..........<<<
<<......<<<<<........<<.<<<........>>>.>>......>>>
>>...<<.<<<..<<.<<<<<.....<<<.<<<<......>>...<<<..
....>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<.<<<..
>>>..>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........
>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>
>>.....<<.<<<................<<<.<<<<....>>>>.>>>.
.............>>>.>>............<<<<<..........>>>>
>...........>>>>>.....<<<<<<<<.......>>>>>>>>.....
.>....>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<
<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>
>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>........
..<<<<<<<<....>>>>>>>>..........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hcf ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		R21 V54 M56 P57 T64 K67 C70 G71 E72 S74 K75 R79 R83 K86
Binding residue
(residue number reindexed from 1)		R4 V37 M39 P40 T47 K50 C53 G54 E55 S57 K58 R62 R66 K69
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6hcf, PDBe:6hcf, PDBj:6hcf
PDBsum6hcf
PubMed30293783
UniProtG1SIZ2|RS20_RABIT Small ribosomal subunit protein uS10 (Gene Name=RPS20)

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