Structure of PDB 8uha Chain V Binding Site BS01

Receptor Information
>8uha Chain V (length=550) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLH
GTPRLEFHQSVFDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLV
KMPSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQ
ALFGDEVSPLLKQYILEKESALFSTELSVLHNFFSPSPKTRRQGEVVQRL
TRMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMSLHDLDVGEIC
TVDPCHKFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSMI
LCDPFAINTLALSTVRHLQELVGQETLPRDSPDLLLLLRLLALGQGAWDM
IDSQVFKEPKMEVELITRFLPMLMSFLVDDYTFNVDQKLPAEEKAPVSYP
NTLPESFTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVETFGD
LAFGDIFLHLLTGNLALLADEFALEDFCSSLFDGFFLTASPRKENVHRHA
LRLLIHLHPRVAPSKLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDHR
Ligand information
Receptor-Ligand Complex Structure
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PDB8uha Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		V326 E329 L331 T371 R372 M378 S379 V382 T386
Binding residue
(residue number reindexed from 1)		V322 E325 L327 T367 R368 M374 S375 V378 T382
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0008283 cell population proliferation
GO:0034244 negative regulation of transcription elongation by RNA polymerase II
GO:0045892 negative regulation of DNA-templated transcription
GO:0048863 stem cell differentiation
GO:2000737 negative regulation of stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0032021 NELF complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uha, PDBe:8uha, PDBj:8uha
PDBsum8uha
PubMed38401543
UniProtQ8WX92|NELFB_HUMAN Negative elongation factor B (Gene Name=NELFB)

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