Structure of PDB 8rhl Chain V Binding Site BS01

Receptor Information

>8rhl Chain V (length=222) Species: 4932 (Saccharomyces cerevisiae)

TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAA
DTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIV
AGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEE
AIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ
KSYKFPRGTTAVLKESIVNICD

Ligand information

>8rhl Chain g (length=4) Species: 32630 (synthetic construct)

FLYG

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8rhl Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): T1 T21 Q22 K33 A46 G47 A49 S129 G168
• Binding residue (residue number reindexed from 1): T1 T21 Q22 K33 A46 G47 A49 S129 G168

Enzymatic activity

• Enzyme Commision number: 3.4.25.1: proteasome endopeptidase complex.

Gene Ontology

Molecular Function

• GO:0004298 threonine-type endopeptidase activity

Biological Process

• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0005839 proteasome core complex

External links

• PDB: RCSB:8rhl, PDBe:8rhl, PDBj:8rhl
• PDBsum: 8rhl
• PubMed: 38628795
• UniProt: P25043|PSB2_YEAST Proteasome subunit beta type-2 (Gene Name=PUP1)