Structure of PDB 7pnu Chain V Binding Site BS01

Receptor Information

>7pnu Chain V (length=365) Species: 10090 (Mus musculus)

LLSAAYVDSHQWEAREKEEYHLADLASLMDKAYERKLPVSSLSISRFVDN
IASREDLDSAEYYLYKFRHSPNCWYLRDWTIHSWIRQCLKYGAQDKALYT
LVNKVQYGIFPDNFTFNLLMDYFIKKGNYKDALSVVFEIMMQEAFDVPST
QFLSLYVLYRCLAEKTELTWEEERDFGASLLLSGLKQRNTVGLSSQLYGY
ALLGKVELQRGVRAVYHGMPLMWTPGYLDRALQVMERVASSPEDLKLGRE
VLDVLDGVLKVVTSPDGSANLVEQLDTEEPEQSKLPRYLERFQASRSKLQ
ELNRVESESLLTLTTQLVKEKLPACEAEDLATYEQKLREWHLERVQLIQR
EQEQREKAKQEYQAL

Ligand information

>7pnu Chain A (length=941)

aaagguuugguccuggccuuauaauuaauuagagguaaaauuacacaugc
aaaccuccauagaccgguguaaaaucccuuaaacauuuacuuaaaauuua
aggagaggguaucaagcacauuaaaauagcuuaagacaccuugccuagcc
acacccccacgggacucagcagugauaaauauuaagcaauaaacgaaagu
uugacuaaguuauaccucuuaggguugguaaauuucgugccagccaccgc
ggucauacgauuaacccaaacuaauuaucuucggcguaaaacgugucaac
uauaaauaaauaaauagaauuaaaauccaacuuauaugugaaaauucauu
guuaggaccuaaacucaauaacgaaaguaauucuagucauuuauaauaca
cgacagcuaagacccaaacugggauuagauaccccacuaugcuuagccau
aaaccuaaauaauuaaauuuaacaaaacuauuugccagagaacuacuagc
cauagcuuaaaacucaaaggacuuggcgguacuuuauauccaucuagagg
agccuguucuauaaucgauaaaccccgcucuaccucaccaucucuugcua
auucagccuauauaccgccaucuucagcaaacccuaaaaagguauuaaag
uaagcaaaagaaucaaacauaaaaacguuaggucaagguguagccaauga
aaugggaagaaaugggcuacauuuucuuauaaaagaacauuacuauaccc
uuuaugaaacuaaaggacuaaggaggauuuaguaguaaauuaagaauaga
gagcuuaauugaauugagcaaugaaguacgcacacccgucacccuccuca
aauuaaauuaaacuuaacauaauuaauuucuagacauccguuuaugagag
gagauaagucguguaagcauacuggaaagugugcuuggaau

..((((..<<<<<<.)))).<<<<<<<.<..<<<<<<<<..<.<<<.<<<
..<......>......<<......<<<<<<<<<..<<<....>>>.>>>>
>>>.>>.<<<....<<...<<....>>..>>......>>>..<<...>>.
>>.<<<....>>>.....>>>>>>>.........<<....<<<<....>>
>>..>>...>>.>>>>>>...<<<<<<<<.....(((.....((.>>>))
.......)))..>>>>>..>.>>>>>>>....<<<((.....<<<<....
<<............<<<<<<....<<<<<<<....<<......>>.....
>>>.>>>..>..........<<....>>.>>>>>>......>>....>>>
>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>...
.......<<<<.<<.......))..>>.>>>>.>>>.<<<.......<<<
....>>>.....>>>..>>>>>><<<<<.<<<<<<........<<<<<..
<<<<<<<<<<.....<<........>>..........<<<<.<<......
.....<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>
>..>>......<<.....>>..........>>>...>>>>>>>>....>>
.>>>>..>>.>>>>>>>>.....<<<<<....>>>>>.....<<..<.<<
<<<<......>>>>>>..>.>>.....>>>>>.....<<<<<<<......
...>>>>>>>............>>>>>>>>>.>>..<<.<...<<<<<<.
...<<<<<....<<....<<.....>>....>>......>>>>>...>>>
>>>....>.>>...<<<<<<<<<....>>>>>>>>>.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7pnu Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
• Resolution: 3.06 Å
• Binding residue (original residue number in PDB): K64 P66 S68 S69 N100 W102 Y103 R105 E386 R393 Q397 E404 Y405 L408
• Binding residue (residue number reindexed from 1): K36 P38 S40 S41 N72 W74 Y75 R77 E343 R350 Q354 E361 Y362 L365

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0005515 protein binding
• GO:0019843 rRNA binding
• GO:0097177 mitochondrial ribosome binding

Biological Process

• GO:0006417 regulation of translation
• GO:0008283 cell population proliferation
• GO:0032543 mitochondrial translation
• GO:0070131 positive regulation of mitochondrial translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7pnu, PDBe:7pnu, PDBj:7pnu
• PDBsum: 7pnu
• PubMed: 35676484
• UniProt: Q8BK72|RT27_MOUSE Small ribosomal subunit protein mS27 (Gene Name=Mrps27)