Structure of PDB 7ohw Chain V Binding Site BS01

Receptor Information

>7ohw Chain V (length=98) Species: 559292 (Saccharomyces cerevisiae S288C)

MNCADNSGARNLYIAASLGDMVMATVKKELRKKVMPAIVVRQAKSWRRRD
GVFLYFEDNAGVIANPKGEMKGSAITGPVGKECADLWPRVASNSGVVV

Ligand information

>7ohw Chain 1 (length=1639)

guuugaccucaaaucagguaggaguacccgcugaacuuauaucaauaagc
ggaggaaaagaaaccaaccgggauugccuuaguaacgcgagugaagcggc
aaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuug
gagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggac
gucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaa
gugccuucgaagagucgaguuguuugggaaugcagcucuaaguggguggu
uccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagu
gauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaa
uuguugaaagggaagggcauuugaucagacaugguguuuugugcccucug
cuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuu
gguggcaggauaaauccauaggaauguagcuugccucgguaaguauuaua
gccugugggaauacugccagcugggacugaggacugcgacguaagucaag
gaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaagg
agucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaauga
acgagguuggggccucgcaagaggugcacaaucgaccgauccugaggaug
gauuugguaagagcauagcuguugggacccgaaagauggugaaaaccauc
uaguagcugguuccugccgaaguuucccucaggauagcagaagcucguau
caguuuuaugaaaaugaagagcuuuuagugggccauuuuugguaagcaga
acuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacac
gcucaucagacacaaaagguguuaguucaucuagacagccggacgguggc
cauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaau
gaacuagcccugaggauggcgcucaagcguguuaccuauacucuaccguc
aggguugauaugaugcccugacgaguaggcaggcguggaggucagugacg
aagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggu
gguaguagcagcgaaaccacagccaaggaacgguugggcuugggcaguca
agcgcgacauugcuauaccgaagcagaauucgguaauguuaccgcaauag
uaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuug
cggcugucuaucaggcauugccgcgaagcuacauccgcuggauuauggcu
gaacgccucuaagucagaauccaugcuagaacgcggugaugcuccacaca
gauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcu
agcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugc
aaugcguggggauaaaucauuuguauacgacuuagauguacaacggggua
uuguaagcagcugcugagauuccuuuguugucugauuug

..........................<<<<<<.....<..>......>>>
>>.>.........<<....>>..<<<<<......<<....>>.....>>>
>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>..
..<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.
((......<<<.....))>>>....>>>>>>>>>..>>>>>>>....>>>
>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<<.
.>>>>>>..>>>..................................<<..
..>>...............<<<......>>>...................
...............<<<<<.<<<<<<.....<<<<...<<<..<<<<<<
<<<.....>>>>>>>>>......>>>...>>>>..<<<<<<<.<<<<<<<
<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>......
.>>>>>>>>..>.>>>>>.>>>>>>>>>>........<<<....>>>...
..>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<.
...<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>.......
....<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<.......>
>>>.>>>>....>>>>>>.>>>>>>..<<.<..<<<<<<<....>>>>>>
>.....>.>>..<<<<<<....<.<........>.><<<<<<<<<....<
<<.<<<<...>>>>>>>..>>>>>>>.>>..<<<<.<<<.<.....>.>>
>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<
<<.....<<.......<<<.<<<<<<<<<<.......<<<<<.<<....<
<.........>>....>>.........<<......>>...>>>>>...>>
>>>>>>>>>>>......))).>>...>>>>>>.>>>>..>>>>>>><<<<
<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<....
..<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>>
<<.....<<.>>....>>....<<<<.......>>>>.....<<<<<...
.<..>....>>>>>.<<<<<<<......>>>>>>>..<<<<<<<<..<<<
<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<
<<<<<<<.<...>.>>>..>>>>>...>>>>.>>>>>.<<<<...<<<<<
...........>>>>>...>>>>.>>>>....>>>>>>>>.<<<<<<...
...<<..........<<<<<<.....>>>>>>......>>.......<<<
<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.......
.....>>>>>>.<<<<<<.<..<.......>..>.....<<<<<<<<<.<
<<....<<<..>>>...>>>.>>>.>>>>>>..>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ohw Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors.
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): R86 R88 F92
• Binding residue (residue number reindexed from 1): R47 R49 F53

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0070180 large ribosomal subunit rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ohw, PDBe:7ohw, PDBj:7ohw
• PDBsum: 7ohw
• PubMed: 34813592
• UniProt: P0CX41|RL23A_YEAST Large ribosomal subunit protein uL14A (Gene Name=RPL23A)