Structure of PDB 7of4 Chain V Binding Site BS01

Receptor Information

>7of4 Chain V (length=191) Species: 9606 (Homo sapiens)

LPPHYRYGMSPPGSVADKRKNPPWIRRRPVVVEPISDEDWYLFCGDTVEI
LEGKDAGKQGKVVQVIRQRNWVVVGGLNTHYRYIGKTMDYRGTMIPSEAP
LLHRQVKLVDPMDRKPTEIEWRFTEAGERVRVSTRSGRIIPKPEWIDGPK
DTSVEDALERTYVPCLKTLQEEVMEAMGIKETRKYKKVYWY

Ligand information

>7of4 Chain A (length=1463)

gcuaaaccuagccccaaaccccaccuuacuaccagacaaccuuagccaaa
ccauuuacauaaaguauaggcgauagaaauugauggcgcaauagauauag
uaccgcaagggaaagaugaaaaaccaagcauaauauagcaaggacuaacc
ccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagag
ccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaa
gagcacacccgucuauguagcaaaauagugggaagauuuauagguagagg
cgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuu
aguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauua
uuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaa
aaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaaca
ucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacgu
uuaacggccgcgguaccgugcaaagguagcauaaucacuuguuccuuaaa
uagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuu
aaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaaga
cgagaagacccuauggagcuuuaauuuauuaaugcaaacaccugcauuaa
aaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguac
augcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuug
accaacggaacaaguuacccuagggauaacagcgcaauccuauucuagag
uccauaucaacaauaggguuuacgaccucgauguuggaucaggacauccc
gauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccua
cgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuu
aauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaag
cgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacc
caagaacaggguu

<<<.......<<<<.................................<..
....>...........<<.....>>.........>>.>>...........
..<<....>>................>>>...........<<<.......
>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....
>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<....
.>>>...<<<<.<<<<........>>>>>>>>....>>>.>>>>>...<<
.......>>......>.>>>>......>.>>..<<<<<<....<<<<...
.>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>
.>..<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>..........................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<
<...>>>>>......<<<...<<<<.......................>>
>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...
<<<<<<<<.<<................<<<<<<..<<<.........>>>
...<<<<<<.............>>>>>>....<<<.<<<..<<<<<..>>
>..>>>>><<<<<..>>>>>........<...........<<<<<<....
.>>>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>
>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<
.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>>>>>>
>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...
..<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>
............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.
......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.
<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>.
.>...>>>>.>....<<<<<<<....>>>.>>>>....>>..>>>.>>..
.<<<.<<<.................>>>.>>><<<<<...<<<....>>>
.>>>>>......<<<................>>>.............<<<
<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of4 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): H18 R20 G22 M23 S24 K34 R40 R41 R42 P43 R83 W85 H94 R96 S111
• Binding residue (residue number reindexed from 1): H4 R6 G8 M9 S10 K20 R26 R27 R28 P29 R69 W71 H80 R82 S97

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of4, PDBe:7of4, PDBj:7of4
• PDBsum: 7of4
• PubMed: 34135319
• UniProt: Q96A35|RM24_HUMAN Large ribosomal subunit protein uL24m (Gene Name=MRPL24)