Structure of PDB 6j50 Chain V Binding Site BS01

Receptor Information

>6j50 Chain V (length=102) Species: 644223 (Komagataella phaffii GS115)

ERACMLCGIVLPGRVFMQNGCPNCDSVLNLRDSDQATVNECTSSSFEGLV
AVGDNEHSWVAKWLRVDRFQPGLYAVRVDGRLPSDIVAALEQYGVYYRPR
DG

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6j50 Chain V Residue 300

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6j50 Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.
• Resolution: 4.7 Å
• Binding residue (original residue number in PDB): C12 C29
• Binding residue (residue number reindexed from 1): C4 C21
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0000993 RNA polymerase II complex binding
• GO:0008270 zinc ion binding

Biological Process

• GO:0006325 chromatin organization
• GO:0006355 regulation of DNA-templated transcription
• GO:0006368 transcription elongation by RNA polymerase II
• GO:0034243 regulation of transcription elongation by RNA polymerase II
• GO:0140673 transcription elongation-coupled chromatin remodeling

Cellular Component

• GO:0000775 chromosome, centromeric region
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0032044 DSIF complex

External links

• PDB: RCSB:6j50, PDBe:6j50, PDBj:6j50
• PDBsum: 6j50
• PubMed: 30733384
• UniProt: C4R0E6