Structure of PDB 6icz Chain V Binding Site BS01

Receptor Information
>6icz Chain V (length=452) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KNSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLS
RSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRN
DKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLK
ECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFK
DHPIILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKY
KAIKKEILTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFPESQTKEL
CNMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFEGIFKEQYDTIHRL
ETNKLRNVAKMFAHLLYTDSWSVLECIKLSEETTTSSSRIFVKIFFQELC
EYMGLPKLNARLKDETLQPFFEDNPRNTRFAINFFTSIGLGGLTDELREH
LK
Ligand information
>6icz Chain U (length=26) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MYNGIGLPTPRGSGTNGYVQRNLSLV
Receptor-Ligand Complex Structure
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PDB6icz Structures of the human spliceosomes before and after release of the ligated exon.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E470 H474 L477 K478 R513
Binding residue
(residue number reindexed from 1)		E281 H285 L288 K289 R324
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0048024 regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6icz, PDBe:6icz, PDBj:6icz
PDBsum6icz
PubMed30728453
UniProtQ9HCG8|CWC22_HUMAN Pre-mRNA-splicing factor CWC22 homolog (Gene Name=CWC22)

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