Structure of PDB 6i7q Chain V Binding Site BS01
Receptor Information
>6i7q Chain V (length=151) Species:
9606
(Homo sapiens) [
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RPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRI
HSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLK
ERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQ
R
Ligand information
>6i7q Chain H (length=17) Species:
9606
(Homo sapiens) [
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LETLAPYIPMDGEDFQC
Receptor-Ligand Complex Structure
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PDB
6i7q
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Resolution
1.798 Å
Binding residue
(original residue number in PDB)
N67 R69 C77 R79 W88 F91 Y98 G104 T105 G106 R107 R108 I109 H110 S111 Y112 H115 W117
Binding residue
(residue number reindexed from 1)
N8 R10 C18 R20 W29 F32 Y39 G45 T46 G47 R48 R49 I50 H51 S52 Y53 H56 W58
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6i7q
,
PDBe:6i7q
,
PDBj:6i7q
PDBsum
6i7q
PubMed
UniProt
P40337
|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)
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