Structure of PDB 6gmr Chain V Binding Site BS01
Receptor Information
>6gmr Chain V (length=149) Species:
9606
(Homo sapiens) [
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RPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRI
HSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLK
ERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAH
Ligand information
>6gmr Chain H (length=16) Species:
9606
(Homo sapiens) [
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EALAPYIPMDDDFQLR
Receptor-Ligand Complex Structure
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PDB
6gmr
Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
Resolution
1.75 Å
Binding residue
(original residue number in PDB)
N67 R69 R79 W88 F91 Y98 P99 G104 T105 G106 R107 R108 H110 S111 Y112 H115 W117
Binding residue
(residue number reindexed from 1)
N8 R10 R20 W29 F32 Y39 P40 G45 T46 G47 R48 R49 H51 S52 Y53 H56 W58
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6gmr
,
PDBe:6gmr
,
PDBj:6gmr
PDBsum
6gmr
PubMed
30040896
UniProt
P40337
|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)
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