Structure of PDB 6elz Chain V Binding Site BS01

Receptor Information

>6elz Chain V (length=134) Species: 559292 (Saccharomyces cerevisiae S288C)

NGAQGTKFRISLGLPVGAIMNCADNSGARNLYIIAVKGSGSRLNRLPAAS
LGDMVMATVKKGKPELRKKVMPAIVVRQAKSWRRRDGVFLYFEDNAGVIA
NPKGEMKGSAITGPVGKECADLWPRVASNSGVVV

Ligand information

>6elz Chain 1 (length=2457)

guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaau
aagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaa
gcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguugua
auuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaac
aggacgucauagagggugagaaucccguguggcgaggagugcgguucuuu
guaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugg
gugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaagu
acagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacg
ugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguu
uugguggcaggauaaauccauaggaauguagcuugccucgguaaguauua
uagccugugggaauacugccagcugggacugaggacugcgacguaaguca
aggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaa
ggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaau
gaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauc
cugaggauggauuugaguaagagcauagcuguugggacccgaaagauggu
gaacuaugccugaauagggugaagccagaggaaacucugguggaggcucg
guucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacu
aaaaccaucuaguagcugguuccugccgaaguuucccucaggauagcaga
agcucguaucaguuuuaugaauguaagaaugaagagcuuuuagugggcca
uuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaa
ggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucu
agacagccggacgguggccauggaagucggaauccgcuaaggagugugua
acaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagc
guguuaccuauacucuaccgucaggguugauaugaugcccugacgaguag
gcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaac
ggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacu
uugaagacugaaguggggaaagguuccacgucaacagcaguuggacgugg
guuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuu
augcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggau
auggauucuucacgguaacguaacugaauguggagacgucggcgcgagcc
cugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauuggu
uuauccggagauggggucuuauggcuggaagaggccagcaccuuugcugg
cuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuu
ucaugccaggucguacugaggucuccaaggugaacagccucuaguugaua
gaauaauguagauaagggaagucggagggucggacgaucaacuuagggaa
ucugaacgagauucccacugucccuaucuacuaucuagcgaaaccacagc
caagggaacgggcuuggcagaaucagcggggacccuguugagcuugacuc
uaguuugacauuauugucagguggggaguaaaguuaccacagggauaacu
ggcuuguggcagucaagcguucauagcgacauugcucggcucuuccuauc
auaccgaagcagaauucgguaagcguuggauuguucacccacuaauaggg
aacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacu
gaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguuc
auucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagc
uaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcua
gaacgcggugauuucuuugcuccacacaauauagauggauacgaauaagg
cguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuugg
cggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcgugg
ggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagca
guagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucu
gauuugu

..........................<<<<<<.....<......>.....
.>>>>>.>...<.....<<....>>..<<<<<......<<.....>>...
..>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>......
..>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......
>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>..
..>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<
<<<<..>>>>>>..>>>....>............................
.<<....>>...............<<<<....>>>>..............
....................<<<<<.<<<<<<.....<<<<<<<.<<<<<
<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>....
...>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.
....>>>>>>>....>>>>>>.>>>>>..<<<<.<....>.>>>><<<<<
<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<
....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<.<<<<
<.......>>>.>>..>>....>>>>>>.>>>>>>..<<.<..<<<<<<<
...<<<<<<<<<....<<<....<<<<<<<....>>>>>>>.....>>>.
<.<<.<<........>>>>.>........>>>>>>>>>.<<<....>.>>
...>>>>>>>.....>.>>..<<<<<<..................<<<<<
<<<<....<<<.<<<<<<<..>>>>>.>>>>>..>>>>>>>.>>..<<<<
.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<
<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<..
.....<<<<<.<<....<<.........>>....>>.........<<...
...>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>
>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>
>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>
>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>
>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>
....((<<<<<<...<<....<<<....>>>........<<<<<<.....
...>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<
<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<
<<<<<<<<<<...((..>>>>>><...<<<<<....<<<<<<....<<<.
....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>
>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>.>>
.>>>>>>>>>>>>..>>....>>>>>.<<<<.....>>>>..>>>>..<<
<<.....<<<<<<<.<<.........<<<<<<..>>>>>...>..<<<<<
<<<....>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<
<<<<........>>>>>....<<<<<..<<..<<<<<.<<<<<<<.<<<<
<.<<<<<<<<....>>>>>>>>..>>>>>.>>>>>..>>>>>>>......
........<<<<<...<<.......>>...>>>>>..<<<..<<<<<..<
.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>
>......>>>.......<<<<<<<....>>>.>>>>.........>>.>>
>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>
>.><<<<<...<<<<...<<<<<<<<<<<))..>>>>>..>>>>>>..>>
>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>
....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<
<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<
<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>
>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<
.....<<<<........>>>>....>>>...>>>....>>>>.>>>>>..
>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6elz Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): T9 K10 R12 S14 G16 P18 A21 I22 K40 G41 G43 R45 L46 N47 R48 L49 K83 R86 F92 N98
• Binding residue (residue number reindexed from 1): T6 K7 R9 S11 G13 P15 A18 I19 K37 G38 G40 R42 L43 N44 R45 L46 K80 R83 F89 N95

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0070180 large ribosomal subunit rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6elz, PDBe:6elz, PDBj:6elz
• PDBsum: 6elz
• PubMed: 29245012
• UniProt: P0CX41|RL23A_YEAST Large ribosomal subunit protein uL14A (Gene Name=RPL23A)