Structure of PDB 5t0h Chain V Binding Site BS01

Receptor Information
>5t0h Chain V (length=480) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQREL
DTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAV
QGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYL
QLLVVIFMMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARV
YEFLDKLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQA
EKLVSKSVFPEQANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAP
QHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAV
RTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRI
SLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIY
STREPQLAFHQRISFCLDIHNMSVKAMRFP
Ligand information
>5t0h Chain e (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MSEKKQPVDLRAELEKHGYKMETS
Receptor-Ligand Complex Structure
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PDB5t0h Structural basis for dynamic regulation of the human 26S proteasome.
Resolution6.8 Å
Binding residue
(original residue number in PDB)		L67 T71 K209 R287 H319 T320 A321 F324 K325
Binding residue
(residue number reindexed from 1)		L50 T54 K192 R270 H302 T303 A304 F307 K308
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0030234 enzyme regulator activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0042176 regulation of protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005838 proteasome regulatory particle
GO:0008541 proteasome regulatory particle, lid subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex
GO:0032991 protein-containing complex
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5t0h, PDBe:5t0h, PDBj:5t0h
PDBsum5t0h
PubMed27791164
UniProtO43242|PSMD3_HUMAN 26S proteasome non-ATPase regulatory subunit 3 (Gene Name=PSMD3)

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