Structure of PDB 4u7u Chain V Binding Site BS01

Receptor Information
>4u7u Chain V (length=355) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSNFINIHVLISHSPSCLNRDDMNMQKDAIFGGKRRVRISSQSLKRAMRK
SGYYAQNIGESSLRTIHLAQLRDVLRQKLGERFDQKIIDKTLALLSGKIS
ADAVTPWVVGEIAWFCEQVAKAEADNLDDKKLLKVLKEDIAAIRVNLQQG
VDIALSGRMATSGMMTELGKVDGAMSIAHAITTHQVDSDIDWFTAVDDLQ
EQGSAHLGTQEFSSGVFYRYANINLAQLQENLGGASREQALEIATHVVHM
LATEVPGAKQRTYAAFNPADMVMVNFSDMPLSMANAFEKAVKAKDGFLQP
SIQAFNQYWDRVANGYGLNGAAAQFSLSDVDPITAQVKQMPTLEQLKSWV
RNNGE
Ligand information
>4u7u Chain X (length=61) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auaaaccgggcucccugucgguuguaauugauaauguugagaguuccccg
cgccagcgggg
.............................................<<<<<
<....>>>>>>
Receptor-Ligand Complex Structure
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PDB4u7u Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli
Resolution3.003 Å
Binding residue
(original residue number in PDB)		N19 R20 D21 D22 K27 S40 Q42 S43 K45 R46 R49 R165 M166 A167 K177 D179 F200 T201 A202 V203 Q234 A265 K266
Binding residue
(residue number reindexed from 1)		N19 R20 D21 D22 K27 S40 Q42 S43 K45 R46 R49 R158 M159 A160 K170 D172 F193 T194 A195 V196 Q227 A258 K259
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0051607 defense response to virus
GO:0099048 CRISPR-cas system
Cellular Component
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4u7u, PDBe:4u7u, PDBj:4u7u
PDBsum4u7u
PubMed25118175
UniProtQ46899|CASC_ECOLI CRISPR system Cascade subunit CasC (Gene Name=casC)

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