Structure of PDB 1lm8 Chain V Binding Site BS01
Receptor Information
>1lm8 Chain V (length=150) Species:
9606
(Homo sapiens) [
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RPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRI
HSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLK
ERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQ
Ligand information
>1lm8 Chain H (length=15) Species:
9606
(Homo sapiens) [
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MLAPYIPMDDDFQLR
Receptor-Ligand Complex Structure
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PDB
1lm8
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
Resolution
1.85 Å
Binding residue
(original residue number in PDB)
N67 N78 W88 F91 Y98 P99 G104 T105 G106 R107 R108 I109 H110 S111 Y112 H115 W117
Binding residue
(residue number reindexed from 1)
N8 N19 W29 F32 Y39 P40 G45 T46 G47 R48 R49 I50 H51 S52 Y53 H56 W58
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:1lm8
,
PDBe:1lm8
,
PDBj:1lm8
PDBsum
1lm8
PubMed
12004076
UniProt
P40337
|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)
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