Structure of PDB 7aju Chain UV Binding Site BS01

Receptor Information

>7aju Chain UV (length=1083) Species: 559292 (Saccharomyces cerevisiae S288C)

ELFKSNIFKLQIDELLEQVKLKQKHVLKVEKFLHKLYDILQEIPDWEEKS
LAEVDSFFKNKIVSVPFVDPKPIPQNTNYKFNYKKPDISLIGSFALKAGI
YQPNGSSIDTLLTMPKELFEKKDFLNFRCLHKRSVYLAYLTHHLLILLKK
DKLDSFLQLEYSYFDNDPLLPILRISCSKDYNFYKTRFSINLLIGFPYKV
FEPKKLLPNRNCIRILPATPLYNFSVLSSSTHENYLKYLYKTKKQTESFV
EATVLGRLWLQQRGFSSNMSHSGSLGGFGTFEFTILMAALLNGGGINSNK
ILLHGFSSYQLFKGVIKYLATMDLCHDGHLQFHSNPASKYIDEGFQTPTL
FDKSTKVNILTKMTVSSYQILKEYAGETLRMLNNVVQDQFSNIFLTNISR
FDNLKYDLCYDVQLPLGKYNNLETSLAATFGSMERVKFITLENFLAHKIT
NVARYALGDRIKYIQIEMVGQKSDFPITKRKVYSNTGGNHFNFDFVRVKL
IVNPSECDKLVTKGPAHSETMSTEAAVFKNFWGIKSSLRRFKDGSITHCC
VWSTSSSEPIISSIVNFALQKHVSKKAQISNETIKKFHNFLPLPNLPSSA
KTSVLNLSSFFNLKKSFDDLYKIIFQMKLPLSVKSILPVGSAFRYTSLCQ
PVPFAYSDPDFFQDVILEFETSPKWPDEITSLEKAKTAFLLKIQEELSAN
SSTYRSFFSRDESIPYNLEIVTLNILTPEGYGFKFRVLTERDEILYLRAI
ANARNELKPELEATFLKFTAKYLASVRHTRTLENISHSYQFYSPVVRLFK
RWLDTHLLLGHITDELAELIAIKPFVDPAPYFIPGSLENGFLKVLKFISQ
WNWKDDPLILDLVKPEERLTLAQYKGIQMNFTNLRNSDPNGTHLQFFVAS
KNDPSGILYSSGIPLPIATRLTALAKVAVNLLQTHGLNQQTINLLFTPGL
KDYDFVVDLRTPIGLKSSCGILSAPSNFPENLNDLSEKMDPTYQLVKYLN
LKYKNSLILSSRKYIGVNGGEKGDKNVITGLIKPLFKGAHKFRVNLDCNV
KPVDDENVILNKEAIFHEIAAFGNDMVINFETD

Ligand information

>7aju Chain D3 (length=1409)

ucugguugauccugccaguagucauaugcuugucucaaagauuaagccau
gcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauu
aaaucaguuaucguuuauuugauaguuccuuacaugguauaacuguggua
auucuagagcuaauacaugcuaucucgacccuuuggaagagauguauuua
uuagauaucuucggacugaugauucauaauaacuuuucgaaucgcauggc
cuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaug
guaggauaguggccuaccaugguuucaacggguaacggggaauaaggguu
cgauuccggagagggagccugagaaacggcuaccacauccaaggaaggca
gcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaa
uaacgauacagggcccauucgggucuuguaauuggaaugaguacaaugua
aauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgc
gguaauuccagcuccaauagcguauauuguuguugcaguuaaaaagcucg
uaguugaacuggcccgguuggccggucggauuuccaacggggccuuuccu
ucuggcuaaccuugaguccuuguggcucuuggcgaaccaguuacuuugaa
aaaauuagaguguucaaagcaggcguauugcucgauauauuagcauggaa
uaauaguaggagguucuauucuaggaccaucguauuaauagggacggucg
ggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaag
acuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaac
gaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccaua
aacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggc
accuuacgagaaaucaaagucuuuggguucugggggaguauggucgcaag
gcugaaaaaggaauugacggaagggcaccaccaggaguggagccugcggc
gcgcuacacugacggagccagcgagaccuuggccgagaggucuugggaaa
cuccgucgugcuggggauagagcauuguaauuauugcucuucaacgagga
auuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccu
uuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccu
caggaucugcuuagagaagggggcaacuccaucucagagcggagauuugg
acaaacuuggucauuugaggaacuaauuccguaggugaaccugcggaagg
aucauuaaa

.<<<<<.......>>>>>.....<<<<<<...<.<..........<<<.<
<<..<<....<<....<<..........>>...>>.>>......<<....
....<<<..<<..<<....<<<..............<.....<<.<<...
....>>.>>......>.....<<<<<..<<....>>..>>>>><...<<<
<<<....<<....>>.<<......>>>>>>>>.....>...<<<<..<<<
.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<
<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>
>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...
>>>>>>.........<<<....<<<.....>>>..>>>.......>.>..
...<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<.....
......>..>>.........<<<<<<.......<<<....>>>.......
...........>>>>>>..>>>>>>..........<<<((.....<.<<.
..<<<.<<..<<<<<.<<<<<.....<>.....>>>>>.>>>>>...<<<
.<<<<.<..<<..<<<<<.....>>>>>..>>..>.>>>><<<<<.<<..
.....<<..<<.......>>.<<<.....>>>...>>......>>.>>..
>>>....>>>..<<.<<<...>>>.>>.......>>....<<<<<<.<<.
..<<<<..<<..<<<<<<.<...<<<..(...>>>......>.>>>>>>.
.>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>
....<<<<<<<...<...<<<<..)......>>>>...>>>>>>>>....
......<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>.
.>>>...<<..))>>...>>.....>>>.>>>..................
...............<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<.>>
>.>>>.....<<<<<<<..........<..<<<<....>>>>..>.....
>>>>>>>...........<<<<<<.<<....>>.>>>>>>..........
>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>
>............>>>>>..<<<<.<<....<<<<<<<<.<<<..<.<<.
.....<<<<<<<..<.<.<<<......>>>.>.>..>>>>>>>.....>>
.>..>>>.>>>>>>>>..>>.>>>>.<<<<<<<<<....>>>>>>>>>..
.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7aju Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): N173 E215 K307 R312 R316 P790 W792 R858 R865 N869
• Binding residue (residue number reindexed from 1): N78 E120 K205 R210 R214 P673 W675 R741 R748 N752

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0006364 rRNA processing
• GO:0006409 tRNA export from nucleus
• GO:0030490 maturation of SSU-rRNA
• GO:0042254 ribosome biogenesis
• GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
• GO:0060962 regulation of ribosomal protein gene transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0030686 90S preribosome
• GO:0032040 small-subunit processome
• GO:0032545 CURI complex
• GO:0034456 UTP-C complex
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7aju, PDBe:7aju, PDBj:7aju
• PDBsum: 7aju
• PubMed: 33326748
• UniProt: P53254|UTP22_YEAST U3 small nucleolar RNA-associated protein 22 (Gene Name=UTP22)