Structure of PDB 6rxz Chain UT Binding Site BS01

Receptor Information
>6rxz Chain UT (length=2028) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSATSGRILKTSRGSKKTPHQKNHRWESFSQKISKLHSLDPLRKVRRHDS
YLRNGLDKWAELNISRPYQAFKREINPLTESLAQILYHEDRIMDLLVEYI
SRHEKEALEPLLDLVTAFAHDLGVRFEKHYPRALSLIVDLAGSMHDVEVI
EWTFAALAFLFKYLSRLLVPDLRPTYDVVAPLMGKAKHPGHIARFSAEAM
SFLVKKAAAPSHKDKALSLFIEHVKKDLESMVGTKQFDLYSQGIMTMFAE
AMKGVGEGLHSTAPDLFSALMRAVPKEELSLPERTVWSDVCCGVITSVIH
HSNTDTFNTVESRVVDDAMACQQQVLFIRVFGTMAGVRKGTRIHDWASFA
KALNQMLVSLGTQAKQIEVMDSSRVWKHIIVNSAIVWSRAPMDALIPAMS
TFQTAMTKEPWMKWYIPFCSYLADQNAERFRGLFLKEFQKFIVAHWSQGN
NEDLLCVLIPRMVESGGLPAPGSKEIFPLPQSWQDQIVSKFVRLEDTCLP
KYSARLRVLKSTTVHPSTNSRIAEVLLKKLKLALRANFITSDGFHAYLRM
CKAPGSIDPSLAPLLRAAAPRFCRSPSFLQALLAYEQEIKHEEHEPLINC
LIANLSSPSHELRLASLQILEVLDFTPDSNNALSIMIQTEEMPLNLQSVR
AIGAHLRRLGLVYSHIEQDSWLARAVPSFLWGMMTVPLAPVWDDAVEAMK
KVAESKHGEEVLANIAFDWLDVPSPQWSGNHGPLTNFECLNLIHLTEAAE
ATNQIIEEPGQDMLSTYEEGQKIIDLRSERARSKALKALAALPWMAERRS
RKLVPHLFAFTDGSWNLADRKDLIKVFSQFSNPRVLYLSQKVYQALLKLL
ANGDIELQKLALKAILTWKSEGIKPYQEHLEYLLDEARFKNELTVLFQGD
NKILPEHRSEVIPVLLHLLYGRAISRKGAASGRHGLHATRLAIIRQLDVE
DMGSFLDIGLGPLRAIRVVDEQGVRESVFAHEPLPPRKQVGLLNMLEAVI
NELGTSVEPYMDALVNSVLYCLVNACRKLNESLYRVIRTTALKSLSRLFQ
NAPDFNWVPYRELMVKEIISPRIEKLPVESTQGVSATWRLMATWSSLPKA
APFLNVDKRILPKIVETLSIEKAKDEVKVFALDILKNLINLAQAPETESQ
FNELIKTELLDPNTDLILKTIGGVLHGQSDIGRELLSSAVDTVVVFAPMI
EVSSHIQDMLEIATWLLNQPLRKVNPKVKGAILLILKRFIELDDLQSNQE
LQRKVYSTISALFGFFKDKQNRQTLAEVLDVFARREWAQEVSDICRGLNS
YVEDYNTRLAAFNSITKTLDQWMPLVHNLLYFIQQPEEFGVLSSNSADGL
CKFISAVESVWATPDQAAWIDVVANIILPAIYAGSRDPSETVRREILRVF
GFLVSHLPQWELVAVSRQLQALRVLEAANDKREFRSKHISQFFIPLFEHF
IFDGLSAQATNTIAALTLSLEWQQYRAILRRFISYVESKPDWQKRVVRLL
EKEVDALRTAVASKKAEIVNNFLPTLLNYIHEVSARVPVGVIIAKLLTLL
PDQLLNEKLPGVLTDICHILRSKAWESREMARDTLSKIAGILGPEKFEFI
VRELRGSLQKGYQLHVLGYTLHSILLVAIPSFPQGSLDYCLGIIMTVIMD
DIFGKSQDSMELLAKTASITRLSELTLPLQSLLMEKLDLRTVRKIDELLL
RITKGLLENASQEVLVFCYEVIQEVYRSQKPEELPKMDPRLKRFIVQAKH
TYKMTRFAIDILRAVMKKHDHLRTAANLIGFLPVLGDAVLAVEEEVKVSA
FKMLTVIVKVPFKNNESNGLYKVAHKEAIKSIAMSSSTQSELAQAALKLI
SVILRDRRDIQMREAALDMLLSKLKDDLTEPLYRHVTFNFLRSVLDRKLE
TASVYDTLDHVGTVMITNDDKDTRDLARGAFFQFLREYPKRNRWEKQLKF
IVANLKYREGGRLSVMECINLLLKKSDEFTQEVAATCFIPLVFVLSDKCR
LAAGELIKETFRVERQSRFLTLLRGWIA
Ligand information
>6rxz Chain C1 (length=1487) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggggggauguccgggucgcccugggcaccucucccggcagccuucgcggg
cagccguagucccgguucauacgucgccgcaaucgcgaggggaccaacgg
guaaccguuccuccaagcggucgccggcgagcaccaccccagccccgcgc
cgcccccagcgcaccgcgcgcaggggggccggcgcggcaucugggaagac
uccuaaggcgcaagggaauaccccgugcgccggggguugggcucuguggg
ugcuuggccgcuggccagaccuacuucaaagccaccggggguaccuaccg
guugucucggucgggccuccucuuggggcgccuaggcggugucuucgggu
cgcgugcagccucccguccucgccugccgacagcgcucuggggaauucag
gaggggaaagcagaugugccccgcggcgagacuggcgcaccgccggacga
gcugcuggggcacgcggguacgcuagccgcacgauaguuaccugguugau
ucugcuagucauaugcuugucucaaauaagccaugcgucuaaguauaagc
aauuacagcgaaacugcgaauggcucauuaaaucaguuaucguuuauuug
auaguaccuuacuauggauaaccgugguaauucuagagcuaauacaugca
aaaucccgacuucggaagggauguauuuauuagagcccuucggggcggug
auucauaauaacuucucgaaucgcacggccuugcgccggcgaugguucau
ucaaauuucugcccuaucaacuuucgacggcuggguauuggccagccgug
gugacaacggguaaggguuagggcucggagaaggagccugagaaacggcu
acuacauccaaggaagggcaggcgcgcaaauuacccaaucccgacacggg
gagguagugacaauaaauacugauacagggcucuuucgggucuuguaauu
ggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagu
cuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucg
uaguugaaccugauuaauagggacagucgggggcgucaguauucaauugu
cagaggugaaauucuuggauuuauugaagacuaacaacugcgaaagcauu
cgccaaggauguuuucauuaaucaggaacgauuagggaucggacggcguu
uauuuuugacccguucggcaccuuacgauaaaucaaaaggaguauggucg
caaggcugaaaaauugacggaagggcaccaccagggguggagccugcgcg
cgcgcuacacugacagagccagcgaguacucccuuggccgagaggcccgg
guaaacucugucgugcugaggaaucccuaguaagcgcaagucaucagcuu
gcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccg
auagaggaaguaggucuccguaggugaaccugcggag
<<<<<<.<<.<<<<<....>>>>>.>>.>>>>>><<<<.<<<<....>>>
>.>>>>.................<<<<<<<.<<<<<..<<<<...<<<<<
....>>>>>.>>>>..>>>>>.>>.>>>>>.......<<<<<..<<<<<<
<<<<<<<.<<<<.....>>>>..>>>>>.>>>>>>>>...>>>>>.....
......<<<<<<.<<<.....>>>.>>>>>>...................
......<<<...>>>.....................<<<<<..<<<<<<<
<.....>>>>>.>>>>>>>>.....<<<<<<...<<<<<<<....<<<<.
.<<.....>>..>>>>....>>>>.>>>....>>>>>>............
...............<<<<<<<<<<<<..<.<<<<<.....>>>>>.>..
>>>>>.>>>>>>><<<<.........>>>>....................
.......<<.<<<<<<...<.<<..<...<<<.<<<<<....<<....<<
.......>>...>>.>>......<<<.......<<<..<<..<<....<<
<.............<<..<..<..<<<.....>>>..>.....>>>....
..<<<<<..........>>>>><...<<<<<<..<<<<....>>>>....
.....>>>>>>.....>...<<<<.<<<<.....>>>>>>>>....>>>.
..>>>>..>>>.<<<....<<.....<<<<<<<<.......>>>>>>>>.
>>......>>>...<<<......>>>.>>>.<<.<<<<........>>>>
.>>.<.<<<..>>>.>.>>>>>>.........<<<....<<<<...>>>>
..>>>..>>...>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>
>>.....<<..<...........>..>>.........<<<<<<.......
<<<....>>>..................>>>>>>..>>>>>>>>.<.<<.
..<<<.<<.....>>....<<.<<<.<<...<<<<..<<<.<<<<<<...
..<<<......>>>........>>>>>>.>>>.......<<....>>...
>>>>..>>.>>>..>>...>>>...>>.>.....<<..<<<<<<<<.<<<
.......>>>>>>>>>>>..>>.....<....>.................
...............<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<..>
>>.>>>.....<<<<<<<..............<<.<<<<....>>>>.>>
.....>>>>>>>..........>>>>>>....<<<<<<<.........>>
>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<.
.....>>.>>>>...<<<<<<<<<....>>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rxz Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		P2 S3 S6 K17 K18 T19 K23 H25 R26 W27 S29 F30 S31 K198 R704 W781 N896 L897 R900 N932 G933 D934 K970 N971 Y1000 I1004 S1005 R1006 K1007 S1011 R1013 H1014 R1020 R1025 R1067 K1068 G1071 L1072 M1075 E1127 L1129 R1131 R1168 K1171 E1175 T1177 Q1178 K1218 Q1614 R1617 A1618 R1940 F1941 L1998 R2071
Binding residue
(residue number reindexed from 1)		P1 S2 S5 K16 K17 T18 K22 H24 R25 W26 S28 F29 S30 K187 R650 W727 N816 L817 R820 N852 G853 D854 K890 N891 Y920 I924 S925 R926 K927 S931 R933 H934 R940 R945 R987 K988 G991 L992 M995 E1031 L1033 R1035 R1072 K1075 E1079 T1081 Q1082 K1122 Q1473 R1476 A1477 R1743 F1744 L1790 R1863
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Cellular Component
GO:0005730 nucleolus
GO:0030686 90S preribosome
GO:0032040 small-subunit processome

View graph for
Cellular Component
External links
PDB RCSB:6rxz, PDBe:6rxz, PDBj:6rxz
PDBsum6rxz
PubMed31378463
UniProtG0SHP3

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