Structure of PDB 7ajt Chain UR Binding Site BS01

Receptor Information
>7ajt Chain UR (length=482) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPPDEEEQLLAKFVFGDTTDLQENLAKFNADFIEAAWIDSDDEKIKVPIL
VTNKTKKLRTSYNESKINGVHYINRLRSQFEKIYPRPKWVDDESDSNGDI
NALTKILSTTYNYKDTLSNSKLLPPKKLDIVRLKDANASHPSHSAIQSLS
FHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLS
NQNQQNIFTAGRRRYMHSWDLSQTAKIEKFSRLYGHESTQRSFENFKVAH
LQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQ
PISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGG
GTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALD
QLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPL
GKVTSVAFSPSGGLLAVGNEQGKVRLWKLNHY
Ligand information
>7ajt Chain D2 (length=446) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
augcgaaagcaguugaagacaagugcuugucguucguuaaaauggccucg
ucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucu
auacagcguguuuaauugacauggguugaugcguauugagagauacaauu
ugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacaguc
ucaucgugggcaucuugcgauuccauuggugagcagcgaaggauuuggug
gauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaau
gccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuc
cucucaaaucagcgauaucaaacguaccccgugaaacaccgggguaucug
uuugguggaaccugauuagaggaaacucaaagagugcuaugguaug
.<<<....>>>...<<<<<<<<<..>>>>>>.>>>..............<
<<<<<<<.<<...<<<<..<<<<<<<<<<<....>>>>.>>>>>>>>>>>
...>>.>>>......>>>>>..<<<<<<..<<<<<..<<<<<.<<<<.<<
<<<<<<....>>>>>>>>.>>>>.>>>>>.>>>>>.>>>>>>.......<
<<<<<<<<<<...........>>>>>.>>>>>>.................
........<<<...>>>.........................<<<<<...
<<<<<<..<<<....<<<<<....>>>>>...>>>..>>>>.>>..>>>>
>.....<<<<<<.....<<<<<<<<<<<<<<........>>>>>>>.>.>
>>>>>......>>>>>>.............................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ajt Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.
Resolution4.6 Å
Binding residue
(original residue number in PDB)		N141 K142 K144 K145 Y150 Q167 I235 R237 Q252 R317 R318 R319 Y320 K341 R344 R353 S354 N380 T517 R535 K538 W555 T557 S558 G559 T560 P561 K564 Q583
Binding residue
(residue number reindexed from 1)		N53 K54 K56 K57 Y62 Q79 I130 R132 Q147 R212 R213 R214 Y215 K229 R232 R241 S242 N268 T405 R423 K426 W443 T445 S446 G447 T448 P449 K452 Q471
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000292 RNA fragment catabolic process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ajt, PDBe:7ajt, PDBj:7ajt
PDBsum7ajt
PubMed33326748
UniProtP40362|UTP18_YEAST U3 small nucleolar RNA-associated protein 18 (Gene Name=UTP18)

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