Structure of PDB 6rxy Chain UR Binding Site BS01

Receptor Information

>6rxy Chain UR (length=447) Species: 209285 (Thermochaetoides thermophila)

AEKDAEEEELEKFVLGAKETFREQLFRDAPAWEDSDDERLTISLAGATRL
RKLRISESEDLVSGIEYARRLRQQYLRLYPQPDWAKPLPLDSFLRDANSF
KVRRKLRPETIDIQRTRDIPDTHKAAISSLAFHPRYPILLSSSTSSIMYL
HKLDASAYPTPNPLLTSVHVKRTDLRRAAFVGPDGGEIIFAGRRRYFHCW
NLSSGLVKKVSKIQGHQKEQRTMERFRVSPCGRYMALVASDKKGGGMLNI
INVGTMQWIAQARIDGRHGVADFAWWSDGNGLTIAGRDGQVTEWSMITRR
TVGIWRDEGSIGGTVMALGGRNGPAELGGDRWVAIGSNSGILNVYDRNDL
IEIRIKKYPTPTRVFEQLTTSISVVAFSPDGQLLAFGSQHKKDALRLVHL
PSCTVYRNWPTEQTPLGRVTAIAFSSKSDVLAVGNDVGRVRLWEIRG

Ligand information

>6rxy Chain C1 (length=1106)

ggggggauguccgggucgcccugggcaccucucccggcagccuucgcggg
cagccguagucccgguucauacgucgccgcaaucgcgaggggaccaacgg
guaaccguuccuccaagcggucgccggcgagcaccaccccagccccgcgc
cgcccccagcgcaccgcgcgcaggggggccggcgcggcaucugggaagac
uccuaaggcgcaagggaauaccccgugcgccggggguugggcucuguggg
ugcuuggccgcuggccagaccuacuucaaagccaccggggguaccuaccg
guugucucggucgggccuccucuuggggcgccuaggcggugucuucgggu
cgcgugcagccucccguccucgccugccgacagcgcucuggggaauucag
gaggggaaagcagaugugccccgcggcgagacuggcgcaccgccggacga
gcugcuggggcacgcggguacgcuagccgcacgauaguuaccugguugau
ucugcuagucauaugcuugucucaaaugacaauaaauacugauacagggc
ucuuucgggucuuguaauuggaaugaguacaauuuaaaucccuuaacgag
gaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuc
caauagcguauauugcucguaguugaaccugauuaauagggacagucggg
ggcgucaguauucaauugucagaggugaaauucuuggauuuauugaagac
uaacaacugcgaaagcauucgccaaggauguuuucauuaaucaggaacga
uuagggaucggacggcguuuauuuuugacccguucggcaccuuacgauaa
aucaaaaggaguauggucgcaaggcugaaaaauugacggaagggcaccac
cagggguggagccugcgcgcgcgcuacacugacagagccagcgaguacuc
ccuuggccgagaggcccggguaaacucugucgugcugaggaaucccuagu
aagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacaca
ccgcccgucgcuacuaccgauagaggaaguaggucuccguaggugaaccu
gcggag

<<<<<<.<..<<<<<....>>>>>..>.>>>>>><<<<.<<<<....>>>
>.>>>>.................<<<<<<<.<<<<<..<<<<...<<<<<
....>>>>>.>>>>..>>>>>.>>.>>>>>....<..<<<<<..<<<<<<
<<<<<<<.<<<<.....>>>>..>>>>>.>>>>>>>>...>>>>>..>..
......<<<<<<.<<<.....>>>.>>>>>>...................
......<<<...>>>.....................<<<<<..<<<<<<<
<.....>>>>>.>>>>>>>>.....<<<<<<...<<<<<<<....<<<<.
.<<.....>>..>>>>....>>>>.>>>....>>>>>>............
...............<<<<<<<<<<<<..<.<<<<<.....>>>>>.>..
>>>>>.>>>>>>><<<<.........>>>>....................
.......<<.<<<<<<...<.<<....>...>.>....<<<<<<<<<<<<
<<....>>>>>>>>>.>>>>>.....<<..<...........>..>>...
......<<<<<<.......<<<....>>>..................>>>
>>>..>>>>>>>>.<.<<...<<<.<<.....>>....<<<<<<.<<...
<<<<..<<<.<<<<<<.....<<<......>>>........>>>>>>.>>
>.......<<....>>...>>>>..>>.>>>.>>>...>>>...>>.>..
...<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>.....<...
.>................................<<<<<<<<<<<<..<<
.<<<<<<..<<<.<<<..>>>.>>>.....<<<<<<<.............
.<<.<<<<....>>>>.>>.....>>>>>>>..........>>>>>>...
.<<<<<<<<.......>>>>>>>>......>>...>>>>>>>........
....>>>>>..<<<<.<<......>>.>>>>...<<<<<<<<<....>>>
>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6rxy Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
• Resolution: 4.7 Å
• Binding residue (original residue number in PDB): R153 R155 K156 Q178 D262 I263 R322 R343 R344 R345 Y346 S361 K362 Q367 S390 K392 K393 H418 R437 S542 H561 K562 N579 E583 Q584 T585 R589
• Binding residue (residue number reindexed from 1): R49 R51 K52 Q74 D112 I113 R172 R193 R194 R195 Y196 S211 K212 Q217 S240 K242 K243 H268 R287 S371 H390 K391 N408 E412 Q413 T414 R418

Gene Ontology

Biological Process

• GO:0006364 rRNA processing

Cellular Component

• GO:0005730 nucleolus
• GO:0032040 small-subunit processome
• GO:0034388 Pwp2p-containing subcomplex of 90S preribosome

External links

• PDB: RCSB:6rxy, PDBe:6rxy, PDBj:6rxy
• PDBsum: 6rxy
• PubMed: 31378463
• UniProt: G0SBN9