Structure of PDB 6zqf Chain UL Binding Site BS01

Receptor Information
>6zqf Chain UL (length=777) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YQRFEQAAAFGVIASNANCVWIPAPGQLITSALEDVNIWDIKTGDLVSKL
SDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGYADGVIKVWDLMSKTV
LLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHK
DSITGFWCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAVK
DDLLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFIT
NSFFYIQNADKTIETFRIYSSFILHPFQTIRSLYKIKSASWTTVSSSKLE
LVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDISDD
NKLLATASNGSLKIWNIKTHKCIRTFECGYALTCKFLPGGLLVILGTRNG
ELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDF
KVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYL
SLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDS
IMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVAT
DGGFVVSSSHDHSIRIWEETSLKAGERLMEALDLGIAEIEGLEAYNRDMK
AVLIAVNKTPEQYIMDTLLRIRMSQLEDALMVMPFSYVLKFLKFIDTVMQ
NKTLLHSHLPLICKNLFFIIKFNHKELVSQKNEELKLQINRVKTELRSAL
KSTEDDLGFNVQGLKFVKQQWNLRHNY
Ligand information
>6zqf Chain D3 (length=1392) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguucauaugcuugucucaaagauuaagccau
gcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauu
aaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugu
gguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagaga
uguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucau
aauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaau
uucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuuca
acggguaacggggaauaaggguucgauuccggagagggagccugagaaac
ggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaa
uucagggagguagugacaauaaauaacgauacagggcccauucgggucuu
guaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagg
gcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauau
uauguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgg
ucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuugugg
cucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagc
aggcguauugcucgaauauauuagcauggaauaauagaauaggacguuug
guucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggu
cgggggcaucaguauucaauugucagaggugaaauucuuggauuuauuga
agacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaaga
acgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaacca
uaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucg
gcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgc
aaggcuaaauuaaaggaauugacggaagggcaccaccaggaguggagccu
gcggcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgag
aggucuugguaaucuugugaaacuccgucgugcuggggauagagcauugu
aauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuu
gcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccg
gaacuaauuccguaggugaaccugcggaaggaucauuaaaga
...<<<<<.......>>>>>...<<<<<<...<.<..........<<<.<
<<..<<....<<....<<..........>>...>>.>>......<<....
....<<<..<<..<<....<<<..................<.....<<.<
<.......>>.>>......>.........<<<<<..<<....>>..>>>>
><...<<<<<<.........(((..<<<....>>>..............>
>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>
..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>....
..>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.........
.>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<..
...>>>..>>>.......>.>.....<<<<<..<.<..........>.>.
.>>.>>>......<<..<...........>..>>.........<<<<<<.
......<<<....>>>..................>>>>>>..>>>>>>..
.......<<<.[.....<.<<...<<<.<<....<<<<<<.<<<<<....
<..>....>>>>>.>>>>>>....<<<<<<....................
...........>>>>>>...<<<<<.<<.......<<...<.......>.
.<<<.....>>>....>>......>>.>>..>>>.........<<...<<
<<<<<<......)))....>>>>>>>>..>>.....>>....<<<<<<.<
<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>
.>.>>......<<<....>>>..>>>>...>>>>>.>>>...>>>...>>
.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..
........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>
>..>>>...<<..].>>...>>.....>>>.>>>................
....................<<<<<<<<<<<<..<<..<<<<<..<<<.<
<<.....>>>.>>>.....<<<<<<<......<<.....<<..<<<<...
.>>>>..>>....>>.......>>>>>>>...........<<<<<<....
......>>>>>>..........>>>>>.....<<<<<<<.........>>
>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<>
>.>>>>.<<<<<<<<<....>>>>>>>>>.............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zqf 90 S pre-ribosome transformation into the primordial 40 S subunit.
Resolution4.9 Å
Binding residue
(original residue number in PDB)		K163 D164
Binding residue
(residue number reindexed from 1)		K150 D151
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0030515 snoRNA binding
GO:0034511 U3 snoRNA binding
Biological Process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6zqf, PDBe:6zqf, PDBj:6zqf
PDBsum6zqf
PubMed32943521
UniProtQ12220|UTP12_YEAST U3 small nucleolar RNA-associated protein 12 (Gene Name=DIP2)

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