Structure of PDB 6zqe Chain UK Binding Site BS01

Receptor Information

>6zqe Chain UK (length=219) Species: 559292 (Saccharomyces cerevisiae S288C)

KLVHDVQKKQHRERSQLTSRSRYGFLEKHKDYVKRAQDFHRKQSTLKVLR
EKAKERNPDEYYHAMHSSMDQVKLLKTQDSNYVRTLRQIELKKLEKGAKQ
LMFKSSGNHTIFVDSREKMNEFTPEKFFNTTSEMVNRSENRLTKDQLANA
SSIMPKESLDKKKLKKFKQVKQHLQRETQLKQVQQRMDAQRELLKKGSKK
KIVDSSGKISFKWKKQRKR

Ligand information

>6zqe Chain D3 (length=1447)

ucugguugauccugccaguagucauaugcuugucucaaagauuaagccau
gcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauu
aaaucaguuaucguuuauuugauagucaugguauaacugugguaauucua
gagcuaauacaugcuaucucgacccuuuggaagagauguauuuauuagau
aaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaa
ucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaa
cuuucgaugguaggauaguggccuaccaugguuucaacggguaacgggga
auaaggguucgauuccggagagggagccugagaaacggcuaccacaucca
aggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagu
gacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugag
uacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugcc
agcagccgcgguaauuccagcuccaauagcguauauuguuguugcaguua
aaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaac
ggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaacc
aggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcuc
gaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguu
gguuucuaggaccaucguaaugauuaauagggacggucgggggcaucagu
auucaauugucagaggugaaauucuuggauuuauugaagacuaacuacug
cgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggg
gaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccga
cuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgaga
aaucaaagucuuuggguucugggggaguauggucgcaaggcuaaaaaagg
aauugacggaagggcaccaccaggaguggagccugcggcgcgcuacacug
acggagccagcgagaccuuggccgagaggucuugggaaacuccgucgugc
uggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaa
gcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacacc
gcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcu
uagagaagggggcaacuccaucucagagcggagauuuggacaaacuuggu
cauuuaggaacuaauuccguaggugaaccugcggaaggaucauuaaa

.<<<<<.......>>>>>.....((((((................[[[.[
[[..<<....<<....<<..........>>...>>.>>......{{....
....[[[..{{..{{....[[[........<<....<<.<<<.....>>>
.>>.....>>.....<<<<<..<<....>>..>>>>>[...((((((...
...<<<<<<<.<<<....>>>....<<......>>)))))).....]...
<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<
<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<
<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<..
..>>.>...]]]]]].........<<<....<<<.....>>>..>>>...
............<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<
<..<...........>..>>.........<<<<<<.......<<<....>
>>..................>>>>>>..))))))..........[[[<<.
......{{...[[[.[[....<<<<<<.<<<<<............>>>>>
.>>>>>>....<<<<<<........<<<<.......>>>>........>>
>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>.
...>>......>>.>>..>>>.........[[...[.(((((......>>
>>>>>..))))).]..]].....]]....<<<<<<.<<...<<<<..<<.
.<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<
<....>>...>>>>..>>.>>>.>>>...]]]...}}......<<<<<<<
...<...<<<...........>>>...>>>>>>>>..........<<<.<
<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..
>>>>...>>.....>>>.]]].............................
....<<<<<<<<<<<<..<<.<<<<<...<<<.<<<.>>>.>>>.....<
<<<<<<.........<<..<<<<....>>>>..>>....>>>>>>>....
.......<<<<<<..........>>>>>>...........>>>>>....<
<<<<<<<.......>>>>>>>>......>>...>>>>>>>..........
..>>>>>..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<
<.<<<<.<<<......>>>.>>>>.>>>>>>>..>..>>.>..>>>.>>>
>>>>>.>>.>>>>.<<<<<<<<<....>>>>>>>>>...........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zqe 90 S pre-ribosome transformation into the primordial 40 S subunit.
• Resolution: 7.1 Å
• Binding residue (original residue number in PDB): K3 V8 Q9 K10 K11 H13 R14 E15 R16
• Binding residue (residue number reindexed from 1): K1 V6 Q7 K8 K9 H11 R12 E13 R14

Gene Ontology

Molecular Function

• GO:0003674 molecular_function

Biological Process

• GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006364 rRNA processing
• GO:0006412 translation
• GO:0030490 maturation of SSU-rRNA
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005732 sno(s)RNA-containing ribonucleoprotein complex
• GO:0032040 small-subunit processome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zqe, PDBe:6zqe, PDBj:6zqe
• PDBsum: 6zqe
• PubMed: 32943521
• UniProt: P34247|UTP11_YEAST U3 small nucleolar RNA-associated protein 11 (Gene Name=UTP11)