Structure of PDB 6rxz Chain UA Binding Site BS01

Receptor Information
>6rxz Chain UA (length=839) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKTNFKFSNLLGTVYCRGNLLFSPDGTHLFSPVGNRVTVFNLVENKSYTF
PFAHRKNISRIGLTPQGNLLLSIDEDGQAILTNVPRRVVLYHFSFKSPVT
ALAFSPSGRHFVVGLKRKIEVWHVPSTPDTNEDGDLEFAPFVRHHTHMQH
FDDVRHLEWSSDSRFFLSASKDLTARIWSLDTEEGFVPTVLSGHRQGVVG
AYFSKDQETIYTVSKDGAVFEWKYVAKPGHEDMQWRIVNKHFFMQNAATL
RCAAYHAESNLLVAGFSNGIFGLYEMPDFNLIHTLSISQNEIDFVTINKS
GEWLAFGASKLGQLLVWEWQSESYILKQQGHFDAMNSLVYSPDGQRIVTA
ADDGKIKVWDVESGFCIVTFTEHTSGVTACEFAKKGSVLFTASLDGSVRA
WDLIRYRNFRTFTAPERLSFTCMAVDPSGEVIAAGSIDSFDIHIWSVQTG
QLLDRLSGHEGPVSSLAFAPDGSVLVSGSWDRTARIWSIFSRTQTSEPLQ
LQSDVLDVAFRPDSKQIAISTLDGQLTFWSVSEAQQVSGVDGRRDVSGGR
RITDRRTAANVAGTKNFNTIRYSMDGTCLLAGGNSKYICLYSTTTMVLLK
KFTVSVNLSLSGTQEFLNSKLMTEAGPVGLLDDQGEASDLEDRIDRSLPG
SKRGDPGARKKFPEVRVSGVAFSPTGNSFCAASTEGLLVYSLDNTVQFDP
FDLNMEITPASTLAVLEKEKDYLKALVMAFRLNEAGLITRVYQAIPYTDI
GLVVEQFPTVYVPRLLRFVAAQTEQSPHMEFCLLWIRALIDKHGPWLAAN
RGKVDVELRVVARAVAKMRDEIRRLADENVYMVDYLLNQ
Ligand information
>6rxz Chain C1 (length=1487) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggggggauguccgggucgcccugggcaccucucccggcagccuucgcggg
cagccguagucccgguucauacgucgccgcaaucgcgaggggaccaacgg
guaaccguuccuccaagcggucgccggcgagcaccaccccagccccgcgc
cgcccccagcgcaccgcgcgcaggggggccggcgcggcaucugggaagac
uccuaaggcgcaagggaauaccccgugcgccggggguugggcucuguggg
ugcuuggccgcuggccagaccuacuucaaagccaccggggguaccuaccg
guugucucggucgggccuccucuuggggcgccuaggcggugucuucgggu
cgcgugcagccucccguccucgccugccgacagcgcucuggggaauucag
gaggggaaagcagaugugccccgcggcgagacuggcgcaccgccggacga
gcugcuggggcacgcggguacgcuagccgcacgauaguuaccugguugau
ucugcuagucauaugcuugucucaaauaagccaugcgucuaaguauaagc
aauuacagcgaaacugcgaauggcucauuaaaucaguuaucguuuauuug
auaguaccuuacuauggauaaccgugguaauucuagagcuaauacaugca
aaaucccgacuucggaagggauguauuuauuagagcccuucggggcggug
auucauaauaacuucucgaaucgcacggccuugcgccggcgaugguucau
ucaaauuucugcccuaucaacuuucgacggcuggguauuggccagccgug
gugacaacggguaaggguuagggcucggagaaggagccugagaaacggcu
acuacauccaaggaagggcaggcgcgcaaauuacccaaucccgacacggg
gagguagugacaauaaauacugauacagggcucuuucgggucuuguaauu
ggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagu
cuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucg
uaguugaaccugauuaauagggacagucgggggcgucaguauucaauugu
cagaggugaaauucuuggauuuauugaagacuaacaacugcgaaagcauu
cgccaaggauguuuucauuaaucaggaacgauuagggaucggacggcguu
uauuuuugacccguucggcaccuuacgauaaaucaaaaggaguauggucg
caaggcugaaaaauugacggaagggcaccaccagggguggagccugcgcg
cgcgcuacacugacagagccagcgaguacucccuuggccgagaggcccgg
guaaacucugucgugcugaggaaucccuaguaagcgcaagucaucagcuu
gcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccg
auagaggaaguaggucuccguaggugaaccugcggag
<<<<<<.<<.<<<<<....>>>>>.>>.>>>>>><<<<.<<<<....>>>
>.>>>>.................<<<<<<<.<<<<<..<<<<...<<<<<
....>>>>>.>>>>..>>>>>.>>.>>>>>.......<<<<<..<<<<<<
<<<<<<<.<<<<.....>>>>..>>>>>.>>>>>>>>...>>>>>.....
......<<<<<<.<<<.....>>>.>>>>>>...................
......<<<...>>>.....................<<<<<..<<<<<<<
<.....>>>>>.>>>>>>>>.....<<<<<<...<<<<<<<....<<<<.
.<<.....>>..>>>>....>>>>.>>>....>>>>>>............
...............<<<<<<<<<<<<..<.<<<<<.....>>>>>.>..
>>>>>.>>>>>>><<<<.........>>>>....................
.......<<.<<<<<<...<.<<..<...<<<.<<<<<....<<....<<
.......>>...>>.>>......<<<.......<<<..<<..<<....<<
<.............<<..<..<..<<<.....>>>..>.....>>>....
..<<<<<..........>>>>><...<<<<<<..<<<<....>>>>....
.....>>>>>>.....>...<<<<.<<<<.....>>>>>>>>....>>>.
..>>>>..>>>.<<<....<<.....<<<<<<<<.......>>>>>>>>.
>>......>>>...<<<......>>>.>>>.<<.<<<<........>>>>
.>>.<.<<<..>>>.>.>>>>>>.........<<<....<<<<...>>>>
..>>>..>>...>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>
>>.....<<..<...........>..>>.........<<<<<<.......
<<<....>>>..................>>>>>>..>>>>>>>>.<.<<.
..<<<.<<.....>>....<<.<<<.<<...<<<<..<<<.<<<<<<...
..<<<......>>>........>>>>>>.>>>.......<<....>>...
>>>>..>>.>>>..>>...>>>...>>.>.....<<..<<<<<<<<.<<<
.......>>>>>>>>>>>..>>.....<....>.................
...............<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<..>
>>.>>>.....<<<<<<<..............<<.<<<<....>>>>.>>
.....>>>>>>>..........>>>>>>....<<<<<<<.........>>
>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<.
.....>>.>>>>...<<<<<<<<<....>>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rxz Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
Resolution4.4 Å
Binding residue
(original residue number in PDB)
R55 Q78 H92 S94 K96 W122 F138 A139 P140 F141 R143 H147 M148 Q149 S179 L180 D181 F186 P188 R195 D216 P228 R244 F250 M252 N254 D410 R413 R415 N416 F417 R418 T419 Q456 T457 G458 R500 T501 N626 S627 K628 R651 I652
Binding residue
(residue number reindexed from 1)
R55 Q78 H92 S94 K96 W122 F138 A139 P140 F141 R143 H147 M148 Q149 S179 L180 D181 F186 P188 R195 D216 P228 R236 F242 M244 N246 D402 R405 R407 N408 F409 R410 T411 Q448 T449 G450 R492 T493 N618 S619 K620 R643 I644
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005730 nucleolus
GO:0032040 small-subunit processome
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6rxz, PDBe:6rxz, PDBj:6rxz
PDBsum6rxz
PubMed31378463
UniProtG0SF93

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