Structure of PDB 7nwg Chain U2 Binding Site BS01

Receptor Information
>7nwg Chain U2 (length=141) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENW
FYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVARR
VLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAAKK
Ligand information
>7nwg Chain A2 (length=1740) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucagaucaaaaccaacccggucaggcggcuuuggugac
ucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucga
acgucugcccuaucaacuuucgaugguagucgccgugccuaccaugguga
ccacgggugacggggaaucaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacuccc
gacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggc
ccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauugg
agggcaagucuggugccagcagccgcgguaauuccagcuccaauagcgua
uauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggg
cggccguccguccccugccucucggcgccccggggcccgaagcguuuacu
uugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuagg
aauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugagg
ccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggu
gaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaag
aauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucaga
uaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcg
uuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuugggu
uccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaag
ggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaa
ccucacccggcccggacacggacaggauugacagauugauagcucuuucu
cgauuccgugggugguggugcauggccguucuuaguugguggagcgauuu
gucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuac
gcgaccccggucggcguaacuucuuagagggacaaguggcguucagccac
ccgagauugagcaauaacaggucugugaugcccuuagauguccggggcug
cacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcag
gcgcggguaacccguugaaccccauucgugauggggaucggggauugcaa
uuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugc
guugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgau
uggaugguuuagugaggcccucggaucggccccgccggggugcccuggcg
gagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucg
uaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<...(((.>>>>><<<.<<<<<<...<.<<..<......<<..
<<<..<<....<.......................>.>>......<<...
.....<<<.<..........<<<...........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<......>>>>>..
.>>>><<..<<<<<.......(((.....<........>......<....
.>..>>>>>......>>...<<<<..<.....>.>>>>....>>>.....
..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>..
....>>>....<<.<<<<....>>>>....>>..>>.<<.<<.<......
...>>>.>>...<<....>>.....>>>.>>.........<<<....<<<
.....>>>..>>>..>...>>.>.....<<<.<<<<..<<<....>>>..
.>>>>..>>>......<<..<...........>..>>.........<<<<
<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>
>.>>>...........<[[.....<.<<...<<<.<<....<<<.<<<<.
<<..>>.>>>>.>>>....<........<<..>.>.....>....<<<<<
<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>
..>>>..........<<.<<<<<<<.........)))...>>>>>>>.>>
......>>....<<<<<<......<<<<...<..<<<<<<<<...<<<..
....>>>......>>>>>>>>..>........<<....>>...>>>>...
..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<....
.>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<
<<<......>>>>>>>>>>.>..>>>...<<..]]>>...>>.....>>>
.>...<<<......<<<......>>>....>>>...)))..<<<<<.<<<
<<<<..<<..<<<<...<<<.<<<<<<......<<........>>.....
.....<<.<<......<<..<<.......<<.<<<........>>>.>>.
....>>..>>...<..<<<..<<.<<<<<.....<<<.<<<<......>>
...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<
<.<.<....>>...>>>>>>>..>>>>..>.....<<<<<.....>>>>>
........>>>.....>>.>>>.....>>>>>.>.......>>.>>...>
>.>>>>.>>>.....<<.<<<................<<<.<<<<....>
>>>.>>>..............>>>.>>.............<<<<......
....>>>>.............>>>>.....<<<<<<<<.......>>>>>
>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<..<...
.<<<<<<<<.<<<..<<.<<<<...<<<<<.<<<<<<<<<..>>>>>>>>
>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>..>>>>...>.>>
...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7nwg Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		V4 Q12 K43 E44 P47 Y48 R56 R62 R67 V72 S74 K77 I78 R82 M88 P89 H91 F92 S96 S98 R101 R121 P125
Binding residue
(residue number reindexed from 1)		V2 Q10 K41 E42 P45 Y46 R54 R60 R65 V70 S72 K75 I76 R80 M86 P87 H89 F90 S94 S96 R99 R119 P123
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7nwg, PDBe:7nwg, PDBj:7nwg
PDBsum7nwg
PubMed34157102
UniProtG1TN62|RS19_RABIT Small ribosomal subunit protein eS19 (Gene Name=RPS19)

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