Structure of PDB 8qbk Chain U Binding Site BS01

Receptor Information
>8qbk Chain U (length=309) Species: 469008 (Escherichia coli BL21(DE3)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAEYLNTFRLRNLGLPVMNNLHDMSKATRISVETLRLLIYTADFRYRIYT
VEKKGPEKRMRTIYQPSRELKALQGWVLRNILDKLSSSPFSIGFEKHQSI
LNNATPHIGANFILNIDLEDFFPSLTANKVFGVFHSLGYNRLISSVLTKI
CCYKNLLPQGAPSSPKLANLICSKLDYRIQGYAGSRGLIYTRYADDLTLS
AQSMKKVVKARDFLFSIIPSEGLVINSKKTCISGPRSQRKVTGLVISQEK
VGIGREKYKEIRAKIHHIFCGKSSEIEHVRGWLSFILSVDSKSHRRLITY
ISKLEKKYG
Ligand information
>8qbk Chain B (length=85) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gtcagaaaaaacgggtttcctggttggctcggagagcatcaggcgatgct
ctccgttccaacaaggaaaacagacagtaactcag
Receptor-Ligand Complex Structure
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PDB8qbk Retron-Eco1 assembles NAD + -hydrolyzing filaments that provide immunity against bacteriophages.
Resolution2.99 Å
Binding residue
(original residue number in PDB)		Y6 F10 R13 N14
Binding residue
(residue number reindexed from 1)		Y4 F8 R11 N12
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006974 DNA damage response
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8qbk, PDBe:8qbk, PDBj:8qbk
PDBsum8qbk
PubMed38788717
UniProtP23070|RT86_ECOLX Retron Ec86 reverse transcriptase (Gene Name=ret)

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