Structure of PDB 8oeq Chain U Binding Site BS01

Receptor Information
>8oeq Chain U (length=144) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLVVQEQGSFQHILRLLNTNIDGRIKIMYALTKIRGVGRRYANLVCKKAD
VELTKRAGELTQEELERIVTIMQNPTNYKIPAWFLNRQKDQVDGKDYHVL
ANNLESKLRDDLERLKKIRSHRGIRHFWGLKVRGQHTKTTSRGR
Ligand information
>8oeq Chain B (length=1712) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguacuacuuggauaaccgugguaa
uucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguau
uuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaa
cuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucug
cccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggg
uaacggggaauaaggguucgauuccggagagggagccugagaaacggcua
ccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacgg
ggagguagugacaauaaauaacgauacaggguuguaauuggaaugaguac
aauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagc
agccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguua
aaaagcucguaguugaaccuugggcuuggcuggccgguccuggacccagc
cgagccuuuccuucuggccaggacuuuuacuuugaaaaaauuagaguguu
caaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggac
guuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagg
gacggucggggguaucaguauucaguugucagaggugaaauucuuggauu
uacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaa
ucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucu
uaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacg
caaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguau
ggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggag
uggagccugcggcuuaauuugacucaacacggggaaacucaccaggucca
gacacaauaaggauugacagauugagagcucuuucuugauuuugugggug
guggugcauggccguucuuaguugguggagugauuugucugcuuaauugc
gauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcug
guauagucacuucuuagagggacuaucgauuucaagucgauggaaguuug
aggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcg
cuacacugacggagccagcgaguauaagccuuggccgagaggucugggaa
aucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcuc
uucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuac
gucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcu
uagugaggccuccggauugguuuagggaaccgagaagcuggucaaacuug
gucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccug
cggaaggaucau
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<
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......<<<..<<..<<....<<<..........<<.....<..<<....
...>>..>......>>........<<<<<..<<....>>..>>>>><...
<<<<<<.......((((((.<<<....>>>..............>>>>>>
.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>
.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>
...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.
>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>
>..>>>..>....>.>.....<<<<...<...>...>>>>......<<..
<...........>..>>.........<<<<<((......<<<<.....<<
..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.
....<.<<...<<<.<<....<<<<<<<<<<<<............>>>>>
>>>>>>>....<<<<<..>>>>>...<<<<<.<<.......<<...<...
....>..<<<....>>>....>>......>>.>>..>>>.........<<
<..<<<<<<<<......))))))...>>>>>>>>>>>.....>>....<<
<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>
.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>
>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>
>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>
>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......
<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<
<..<<<.<<<<<<......<<........>>..........<<<<<....
..<<<<<........<<.<<<........>>>.>>......>>>>>...<
<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>
>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>
>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>
>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>
>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>..
..>>.......>>>>>>>...........<<<<<<..........>>>>>
>..........>>>>>>....<<<<<<<<.......>>>>>>>>......
>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<
.<<<..<<<<..<...<<<<.........>>>>...>..>>>>..>>>.>
>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>
>>>>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Resolution3.3 Å
Binding residue
(original residue number in PDB)
K27 Y30 G37 V38 G39 R40 R41 Y42 W84 F85 N87 R88 Q89 K90 Q92 L109 D112 H122 R123 R126 H127 K132 V133 R134 G135 Q136 H137 T138 K139 T140 T141 R143
Binding residue
(residue number reindexed from 1)
K26 Y29 G36 V37 G38 R39 R40 Y41 W83 F84 N86 R87 Q88 K89 Q91 L108 D111 H121 R122 R125 H126 K131 V132 R133 G134 Q135 H136 T137 K138 T139 T140 R142
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