Structure of PDB 8esr Chain U Binding Site BS01

Receptor Information

>8esr Chain U (length=98) Species: 4896 (Schizosaccharomyces pombe)

SNKYIIDATAAVNDKIFDVAAFEKYLIDRIKVDGKTGNLGSSVVVSREGS
SKIAVIAHIDFSGRYLKYLTKKFLKKHSLRDWLRVVSTKKGVYELRYY

Ligand information

>8esr Chain 1 (length=2143)

uugaccucaaaucagguaggacuacgcgcugaacaauaagcgcaggaaaa
gaaaauaaccaugauucccucaguaacggugaagcgggaaaagcucaaau
uugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaag
cugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucag
agagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgc
uuucgaagagucgaguugugcagcucuaaaugggugguucaucuaaagcu
aaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagauga
aaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaaggga
agcauuggaaaucaggucagcaucaguuuucgggggcggaaaaagaauaa
gggaagguggcuguuuauagcccuuguuguaauacguccacuggggacug
aggacugcggcuugccaaggaugcugacauaaugguuuucaauggcccgu
cuugaaacacggaccaaggagucuagcaucuaugcgaguguuugggugau
gaaaacccauccgcgaaauggugaaugcaggugggaacgcccuggcgugc
accaucgaccguaagagcauagcuguugggacccgaaagauggugaacua
ugccugaauuggguauaggaaccaucuaguagcugguuccugccgaaguu
uccggauagcagaaacucagaucaguuuuauguguaaaaugagaguuucu
agugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacg
ugagguuaaggugccggaauguacgcucaucagagaaaagguguuaguuc
aucuagacagcaggacgguggccauggaagucggaauccgcuaaggagug
uguaacaacucaccugccgaaugaacuagcccugaaaauggauggcgcuu
aagcguacuacccauaccucaccgucuggguuagagaagcucagacgagu
aggcaggcguggagguuugugacgaagccuugggcgugagccugggucga
acagccucuagugcagaucuugguggaaguagcauucaaaugagaacuuu
gaagacugaaguggggaaagguuccaugugaacagcaguuggacaugggu
uagucgauccuaagagauagggaagcuccguaugaaaguugcacgauuuu
ucgugccuaucgaaagggaauccgguuaauauuccggaaccagaaggugg
aaucacggcaacguaaaugaaguuggagacgucggcgggagcccugggaa
gaguucucuuuucuuuuuaacaaaccacacccugaaaucgguuuauccgg
agcuaggguaugguguuuggaagaguucagcggcugaauccggugcgcuc
ucgacggcccuugaaaauccaacggaagguuuucacaucuggucguacuc
cuccaaggugccucuaguugauagaacaauguagauaagggaagucggca
aaaugggcccacugucccuaucuacuaucuagcgaaaccacagccugggg
aacgggccaggcaaaaucagcggcccuguugagcuugacucuaguuugca
gguggggaguuaaaguuaccacagggaucuuguggcagccaagcgcgacg
uugcuucggcucuuccuaucauaccgaagcagaauucgguaagcguugga
cccacuaauagggaacgugagcugggaccgucgugagacgguuagucuac
ugaugaagugucgucgcaaugguaauucaacuuaguacgagaggaaccgu
ugauucagaucauugguauuugcggcugccugacaaggcaaugccgcgga
gcuaucaucugccggauaacggcugaacgccucuaagccagaauccgugc
cagaaagcgacgauauguauaaaaauagagguaggcuacucuccuguauc
guagaagaugggcgaugguugaugaaacggaaguguuuuauugacuuguc
caugaaauuccaugaauccauugcauacgacuuuaauguggaacggggua
uuguaagcagcugcugagauuaagccuuuguucccaagauuug

........................<<<<<<........>>>>>.>.....
....<<....>>..<<<<<......<<.>>.....>>>>>..<<<..<<.
......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<
<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((...
...<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>
>.>>........<<<<<<..>>>>>>.....<<<<<<.>>>>>>..>>>.
.................................<<....>>.........
......<<<<....>>>>................................
..<<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<
<<<......<...>......>>>>>>>>......>>>>>.>>>>>>>>>>
........<<<..>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<
........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<...
....>>>>...>>>...<<.>>.......<<<<<..<<<<<..>>>>>..
.>>>>>.<<.>>....>>>>>>.>>>>>>..<<.<...<<<<<<...<<<
<<<<<<<.>>>>>>>>>>..>>>>>>......>.>>..<<<<<<......
<<..>>..<<<<<<<<<....<<<.<<<<<<..>>>>>>>>>.>>>>>>>
.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<
<<<<<<...<<<(((.....<<<<<<.....<<.....<<<.<<<<<<<<
<<.......<<<<<.<<....<<.........>>....>>.........<
<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>.
..>>>>>>.>>>...>>>>>>><<<<<<<<<.......>>>>>>>>>...
.>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...
>>>>>>>>>>........>>>>>><<.....<<.<<<<<<.......>>>
>>><<<<.....<<<...<<...<<<<<<.............>>>>>>..
..((<<<<<<...<<....<<<....>>>...........<<<<<.....
.>>>>>...>>....>>...<<<<<........>>>>>))<<<<..<<<<
<<..<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<
<<<...((..>>>>>>....<<<<<...<<<<<<....<<<.....>>>.
...>>>>>>.....>>>>>.....<<<<<<<.>>>>>>>>>>>...>>>>
>>>.>>>>.........>>>>>>......>>>.>>>.>>>>>>>>..>>.
.>>>.<<<..>>>..>>>>..<<<<.....<<<<<<<.<<.........<
....<<..>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<..
......>>>>>....<<<<<.<.<<<<<.<<<<<<<<<<<<<.<<<<..>
>>>..>>>>>>.>>>>>..>>>>>>>.......<<<<<<...<..>...>
>>>>>.<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.
.>>>.....>>>>.......>>>>.<<<<<<<....>>>>>>>....>.>
>>>>.....<<<<<<<<..<<<<.<.<<<<<.................>>
>>>.><<<<<...<<<<....<<<<<<<<<<))..>>>>>..>>>>>...
>>>>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>
>>....>>>>>>>>....<<.......<<<<..<..>..>>>>....>>.
.......<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>
>>>..........<<<<<.<.............>.....<<<<<<<<<.<
<<....<<<..>>>...>>>....>>>>.>>>>>...>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8esr Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): Y73 S95
• Binding residue (residue number reindexed from 1): Y65 S87

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8esr, PDBe:8esr, PDBj:8esr
• PDBsum: 8esr
• PubMed: 36423630
• UniProt: Q09668|RL22_SCHPO Large ribosomal subunit protein eL22 (Gene Name=rpl22)