Structure of PDB 8cvo Chain U Binding Site BS01

Receptor Information
>8cvo Chain U (length=84) Species: 1747 (Cutibacterium acnes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRSLKKGPFVDEHLAKKVTAQNEAGTHNVIKTWSRRSMVTPDMIGHTIGV
HDGRKHVPVFVTESMVGHKLGEFAPTRTFKGHVK
Ligand information
>8cvo Chain A (length=471) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gacggggccccgcacaagcggcggagcaugcggauuaauucgaugcaacg
cguagaaccuuaccuggguuugacauggaucgggagugcucagagauggg
ugugccucuuggucgguucacagguggugcauggcugucgucagcucgug
ucgugagauguuggguuaagucccgcaacgagcgcaacccuuguucacug
uugccagcacguuaugguggggacucaguggagaccgccggggucaacuc
ggaggaagguggggaugacgucaagucaucaugccccuuauguccagggc
uucacgcaugcuacaauggcugguacagagaguggcgagccugugagggu
gagcgaaucucggaaagccggucucaguucggauuggggucugcaacucg
accucaugaagucggagucgcuaguaaucgcagaucagcaacgcugcggu
gaauacguucccggggcuugu
.<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........
>>..........<<<<<<<......<<<<<.<....<<<<<<....>>>>
>>...........>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<
<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<
...<<..<<<......>>>>>....>>>>>>>.....<<<<<.....>>>
>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>..
.>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>
..>>....>>>.....>>>>>>>......<....<<<<<<<........>
>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>
......>>...>>>>>>>>>>
Receptor-Ligand Complex Structure
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PDB8cvo Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		P2 R3 S4 L5 K6 K7 F10 H14 K18 W34 R36 R37 H52 G54 R55 K70 G72 E73 T77 R78 T79 F80 H83
Binding residue
(residue number reindexed from 1)		P1 R2 S3 L4 K5 K6 F9 H13 K17 W33 R35 R36 H51 G53 R54 K69 G71 E72 T76 R77 T78 F79 H82
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cvo, PDBe:8cvo, PDBj:8cvo
PDBsum8cvo
PubMed36864821
UniProtQ6A6N0|RS19_CUTAK Small ribosomal subunit protein uS19 (Gene Name=rpsS)

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