Structure of PDB 8csq Chain U Binding Site BS01

Receptor Information

>8csq Chain U (length=174) Species: 9606 (Homo sapiens)

RKTRHDPLAKSKIERVNMPPAVDPAEFFVLMERYQHYRQTVRALRMEFVS
EVQRKVHEARAGVLAERKALKDAAEHRELMAWNQAENRRLHELRIARLRQ
EEREQEQRQALEQARKAEEVQAWAQRKEREVLQLQEEVKNFITRENLEAR
VEAALDSRKNYNWAITREGLVVRP

Ligand information

>8csq Chain A (length=802)

auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaag
ggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagcc
acacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaagu
uuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccacc
gcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuu
uagaucaaauaaagcuaaaaaaauagacuacgaaaguggcuuuaacauau
cugaacacacaauagcuaagacccaaacugggauuagauaccccacuaug
cuuagcaacaguuaaaucaacaaaacugcucgccagaacacuacgagcca
cagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggag
ccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucag
ccuauauaccgccaucuuaacccugaugaaggcuacaaaguacguuaggu
caagguguagcccaugagguggcaagaaaugggcuacauuuucuacccca
gaaaauuuagcaguaaacugagaggcuuaguugaacagggcccugaagcg
cgucgucacccuccucaaguauacuucaaaggacauuuaacuaaaacccc
uacgcauuuauauagaggagacaagucguaaaguguacuggaaagugcac
uu

..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<
..<......>......<<.......<<<<.<..<<<.....>>>.>..>>
>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.
>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>
>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>
)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..
<<<<.....<<<<<<..............<<....>>.>>>>>>.....>
>>>...>>>>.....<<<<<...<<...<<<<.........>>>>...>>
>>>>>.<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<..
..>>>>.....>>..>>>>>>.....<<<<<<<<...<<<.<<<<<.<<<
<<<<<<<<......<<................>>.<<<<<<<.......<
<.<<<..<<<<<<<.<...<<<<<.....>>>.......>>..>.>.>>>
...>>>>>>>>....>>>>>>>..>>>.>>>>>>>.>...<<<<.....>
>>>..>>>>>.....<<<<<<<...>>>>>>>.....>>>...>>>>>>>
>..<<.....<<<<<<..<<<<<......<<<...<<<.....>>>..>>
>.......>>>>>.>>>>>>......>>..<<<<<<<<<....>>>>>>>
>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8csq Principles of mitoribosomal small subunit assembly in eukaryotes.
• Resolution: 2.54 Å
• Binding residue (original residue number in PDB): R27 K28 T29 R30 D32 L34 A35 S37 K38 R41 N43 P46 F53 L56 Y60 R64 R71 M72 V75
• Binding residue (residue number reindexed from 1): R1 K2 T3 R4 D6 L8 A9 S11 K12 R15 N17 P20 F27 L30 Y34 R38 R45 M46 V49

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8csq, PDBe:8csq, PDBj:8csq
• PDBsum: 8csq
• PubMed: 36482135
• UniProt: Q9BYN8|RT26_HUMAN Small ribosomal subunit protein mS26 (Gene Name=MRPS26)