Structure of PDB 8c99 Chain U Binding Site BS01

Receptor Information
>8c99 Chain U (length=102) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINLVKKHQKPVPA
LNQPGGIVEKEAAIQVSNVAIFNAATGKADRVGFRFEDGKKVRFFKSNSE
TI
Ligand information
>8c99 Chain A (length=945) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcua
aucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauu
uccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauc
cauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccga
ggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggag
cagcccagagccugaaucaguguguguguuaguggaagcgucuggaaagg
cgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugag
cucgaugaguagggcgggacacgugguauccugucugaauaugggggauc
cuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugag
ggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaacc
guguacguacaagcagugggagcacgcuuaggcgugugacugcggucagc
gacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaac
cgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggug
aucaccgggagauagcugguucuccccgaaagcuauuuagguagcgccuc
gugaauucaucuccgggggagaauguuaucacgggagacacacggcgggu
gcuaacguccgucgugaagagggaaacaacccagaccgccagcuaagguc
ccaaagucaugguuaagggggcuaaaccaugcaccgaagcugcggcagcg
acgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggug
ugcugugaggcaugcuggagguaucagaagugcgaaugcugacau
.<<<<<<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<.[..
(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...
>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.....
....>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.
>.........<<....>>...<<<<<.....<<.....>>....>>>>>.
..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>
>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>
>>>........<.<.<<<<.........>>>>.>.>......<<<<<..>
>>>>..>>>......>>.>>>>>>>.>>...............<<....>
>....>>.........<<<<.....>>>>.............>....>>>
>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>.<<<<<<
....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>
>...<........>.......>>>>>>>>>>>>>..<<.<..<<<<<<<.
...>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<
<<<<...<<<<<<<...>>>>.>>>...>>>>>>>.>...<<<<<<<<<.
.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(
((.....<<<<<<....))).....>>>>>>.>>>...>>>>>>><<<<<
<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<
<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8c99 Cryo-EM captures early ribosome assembly in action.
Resolution3.29 Å
Binding residue
(original residue number in PDB)		K3 R5 R6 G15 K16 K18 V27 K43 H44 K46 P47 G56 Q65 S67 N68 R81 F84 F86 K91 K96
Binding residue
(residue number reindexed from 1)		K3 R5 R6 G15 K16 K18 V27 K43 H44 K46 P47 G56 Q65 S67 N68 R81 F84 F86 K91 K96
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8c99, PDBe:8c99, PDBj:8c99
PDBsum8c99
PubMed36797249
UniProtP60624|RL24_ECOLI Large ribosomal subunit protein uL24 (Gene Name=rplX)

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